{"id":"W4396500010","doi":"10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7188","title":"Desensitization of the Muscarinic M3 Receptor Inhibits Airway Hyperresponsiveness in a Murine Model of Asthma","year":2024,"lang":"en","type":"article","venue":"","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Institute for Research in Immunology and Cancer","funders":"","keywords":"Desensitization (medicine); Airway hyperresponsiveness; Muscarinic acetylcholine receptor; Asthma; Immunology; Bronchial hyperresponsiveness; Medicine; Receptor; Internal medicine; Lung; Respiratory disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005491067,0.0007586458,0.0007286525,0.0006608816,0.0004142117,0.0003859394,0.0006188511,0.00104933,0.001705055],"category_scores_gemma":[0.0003579289,0.0004107606,0.0007975913,0.0001978738,0.0007632967,0.0004714895,0.0002799971,0.002926358,0.0006006798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005398961,"about_ca_system_score_gemma":0.00042364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007889591,"about_ca_topic_score_gemma":0.002033629,"domain_scores_codex":[0.9994488,0.0001307859,0.00003840283,0.00005277585,0.0001225217,0.0002067701],"domain_scores_gemma":[0.9996846,0.00006078468,0.00006564111,0.0000634497,0.00002168631,0.000103845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001007972,0.0006192037,0.0001154653,0.00003248495,0.00001077439,0.00009371769,0.00003315151,0.0002034313,0.9964978,0.0001438313,0.0001104975,0.001131717],"study_design_scores_gemma":[0.0005464093,0.01195949,0.006698068,0.000033861,0.00005887985,0.0004553852,0.0001264336,0.002937751,0.9748328,0.0002652899,0.002062244,0.00002335568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965826,0.0006910897,0.0008158048,0.0002719213,0.0001142063,0.00007115064,0.0001895699,0.0001009301,0.001162834],"genre_scores_gemma":[0.9931213,0.0008277608,0.001234101,0.0002259614,0.00005643414,0.0001199699,0.0004616991,0.00004134673,0.003911378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001705055,"threshold_uncertainty_score":0.005703986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539238240977112,"score_gpt":0.2644536435736528,"score_spread":0.2490612611638817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}