{"id":"W4396500698","doi":"10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a3296","title":"Polygenic and Transcriptional Risk Scores Identify Chronic Obstructive Pulmonary Disease Subtypes","year":2024,"lang":"en","type":"article","venue":"","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital","funders":"","keywords":"Pulmonary disease; Disease; Polygenic risk score; Medicine; Internal medicine; Computer science; Computational biology; Gene; Biology; Genetics; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001111212,0.0006330959,0.000581587,0.001332009,0.000559235,0.001500623,0.0004510437,0.0009125581,0.003499025],"category_scores_gemma":[0.003905674,0.0002666062,0.001231124,0.001411294,0.0005017814,0.0005698093,0.0009235211,0.001198232,0.0006025129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002528076,"about_ca_system_score_gemma":0.0003081218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002344639,"about_ca_topic_score_gemma":0.003427333,"domain_scores_codex":[0.9987609,0.0003992765,0.00008635635,0.0003491432,0.000159966,0.0002442925],"domain_scores_gemma":[0.9972,0.00107634,0.0008367075,0.0003405378,0.000204405,0.0003420294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004402901,0.00005735911,0.9878591,0.00002234865,0.0005039562,0.0001112422,0.00009206364,0.0005115044,0.003940037,0.0003113404,0.0003203778,0.005830313],"study_design_scores_gemma":[0.00001664022,0.0001030422,0.9946062,0.00001276083,0.000217936,0.0003001065,0.0001639046,0.002614074,0.0003898958,0.001199055,0.0003603442,0.00001612136],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959295,0.0005160527,0.001275344,0.0002422871,0.0000314085,0.000007768754,0.0009226552,0.00002247725,0.001052384],"genre_scores_gemma":[0.9983065,0.00009962454,0.0002926534,0.00006510921,0.00005037351,0.000006644242,0.0007017893,0.00001521477,0.0004620702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003499025,"threshold_uncertainty_score":0.0117054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485165859257909,"score_gpt":0.2948179080338992,"score_spread":0.2799662494413201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}