{"id":"W4396501948","doi":"10.21203/rs.3.rs-4331810/v1","title":"Differential contributions of circadian clock genes to cell survival in bipolar disorder patient derived neuronal progenitor cells distinguishes lithium responders and non-responders","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; Canadian Institutes of Health Research","keywords":"Circadian rhythm; Bipolar disorder; Progenitor cell; Lithium (medication); Molecular clock; Circadian clock; Gene; Biology; Neuroscience; Cancer research; Cell biology; Endocrinology; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008727009,0.00008708828,0.0001829454,0.0003984567,0.0001573866,0.0004482224,0.00009580165,0.0001299981,0.002255121],"category_scores_gemma":[0.0003808946,0.00007416056,0.0001127945,0.0002879345,0.0001092582,0.0001063444,0.0001272752,0.0002034615,0.0002732516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001410666,"about_ca_system_score_gemma":0.0001264262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001396355,"about_ca_topic_score_gemma":0.002037657,"domain_scores_codex":[0.9999448,0.000008009499,0.000006462032,0.00001059885,0.00001140897,0.00001868469],"domain_scores_gemma":[0.9998719,0.00003216672,0.00003381527,0.00001057105,0.00002246567,0.00002917333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006375576,0.0001313377,0.149147,0.00009106565,0.00006745967,0.0005215221,0.000984555,0.0001390892,0.8159914,0.000304985,0.0005140209,0.02573195],"study_design_scores_gemma":[0.00007199682,0.001050964,0.921783,0.000027883,0.0001121182,0.001336747,0.001636682,0.0004214725,0.07157058,0.0002479196,0.001724419,0.00001624098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991079,0.0001868716,0.00006405061,0.00001575968,0.000003457231,0.000002711966,0.0002825997,0.000004302384,0.0003323074],"genre_scores_gemma":[0.9981803,0.0002498885,0.0001188814,0.00002450285,0.000005256547,0.00001246879,0.0006357978,0.00001273884,0.0007601956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002255121,"threshold_uncertainty_score":0.0075441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0339563482215447,"score_gpt":0.3276380648500844,"score_spread":0.2936817166285397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}