{"id":"W4396504824","doi":"10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a1057","title":"Clinical Stage Drug Candidate LAU-7b Shows Potent Antifibrotic Properties in Several Preclinical Models of Pulmonary Fibrosis","year":2024,"lang":"en","type":"article","venue":"","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Vertex Pharmaceuticals (Canada)","funders":"","keywords":"Stage (stratigraphy); Medicine; Pulmonary fibrosis; Drug; Fibrosis; Drug candidate; Pharmacology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004470961,0.0005419467,0.0006587696,0.0004171849,0.000262696,0.0003580103,0.0003385101,0.0004569791,0.004013963],"category_scores_gemma":[0.0002138894,0.0001383898,0.0004159866,0.0002068508,0.0003217398,0.0003022746,0.0001656449,0.001495297,0.0008920582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002300845,"about_ca_system_score_gemma":0.0005026557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004159265,"about_ca_topic_score_gemma":0.001711989,"domain_scores_codex":[0.9998802,0.00003033532,0.000008018649,0.000009944608,0.00003300457,0.00003849627],"domain_scores_gemma":[0.9998271,0.00002669944,0.00002748777,0.00001378567,0.00003190748,0.0000729516],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007345207,0.00402656,0.0007679823,0.0004691824,0.00009128295,0.0004176174,0.00005930499,0.0008462917,0.9467896,0.0003010352,0.002412625,0.03647324],"study_design_scores_gemma":[0.002887633,0.08299489,0.008483681,0.00008415585,0.0002485784,0.001086943,0.0001098292,0.0021061,0.8819089,0.0002227951,0.0198286,0.00003785514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796708,0.01018448,0.002504895,0.0009111973,0.000248662,0.000270049,0.001157899,0.0002728009,0.004779335],"genre_scores_gemma":[0.9795235,0.006834224,0.002582647,0.0003133584,0.00009366665,0.0001688123,0.003692368,0.0000360474,0.006755444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004013963,"threshold_uncertainty_score":0.01342803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04676264982968705,"score_gpt":0.3248525281132969,"score_spread":0.2780898782836099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}