{"id":"W4396505237","doi":"10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2282","title":"Trametinib and Lymphangiectasia in Noonan Syndrome: A Success Story","year":2024,"lang":"en","type":"article","venue":"","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital","funders":"","keywords":"Noonan syndrome; Trametinib; Computer science; Medicine; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003054937,0.0009575708,0.001619624,0.0006177915,0.001009321,0.002162934,0.0007968969,0.008322636,0.001608188],"category_scores_gemma":[0.007768471,0.0002903532,0.0009029481,0.0005800931,0.001729936,0.004238696,0.001340339,0.009718007,0.001114254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001527056,"about_ca_system_score_gemma":0.001183328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069583,"about_ca_topic_score_gemma":0.001698631,"domain_scores_codex":[0.9989292,0.0002122022,0.0001534678,0.0001417132,0.0003834995,0.0001799273],"domain_scores_gemma":[0.9953376,0.003155631,0.0002843291,0.0001514187,0.0004678416,0.0006032183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.002407746,0.0005747201,0.01443266,0.0007949746,0.0006703876,0.1088701,0.0004804644,0.001594723,0.004861522,0.06303204,0.2490467,0.553234],"study_design_scores_gemma":[0.001913155,0.001978614,0.01075572,0.001470212,0.0007869907,0.1154894,0.0007978989,0.00360866,0.004371735,0.09791656,0.7606178,0.0002933274],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.03577556,0.2919936,0.002526752,0.645573,0.0108693,0.00003331879,0.00029639,0.0001723969,0.01275974],"genre_scores_gemma":[0.3941311,0.3309641,0.00488718,0.1758619,0.07019941,0.0001282112,0.0005407921,0.0001551196,0.02313205],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008322636,"threshold_uncertainty_score":0.0161562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005294998040030858,"score_gpt":0.2450914845037772,"score_spread":0.2397964864637463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}