{"id":"W4396506827","doi":"10.1371/journal.pbio.3002605","title":"Single-cell RNA-seq of Drosophila miranda testis reveals the evolution and trajectory of germline sex chromosome regulation","year":2024,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Biology; Dosage compensation; Genetics; Autosome; Germline; Y chromosome; X-inactivation; Gene; X chromosome; Meiosis; Gene dosage; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001370106,0.0001110017,0.0001879749,0.00003854336,0.00003833086,0.000007917899,0.000108734,0.0001673011,0.00004819],"category_scores_gemma":[0.00007124583,0.00007834821,0.00007534013,0.00007358837,0.0003524687,0.000004000265,0.00005664975,0.00006834276,0.000002401768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008699499,"about_ca_system_score_gemma":0.00004027818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001247755,"about_ca_topic_score_gemma":0.000006208359,"domain_scores_codex":[0.9991361,0.00008527415,0.000343757,0.0002385521,0.00007238099,0.0001239449],"domain_scores_gemma":[0.9995112,0.00009036026,0.0001076497,0.0001782351,0.0000777009,0.00003487096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002857758,0.00008951934,0.001380557,0.0001428456,0.00003802753,7.261272e-7,0.00008262243,0.000005184246,0.9956369,0.0005769111,0.000104491,0.001913684],"study_design_scores_gemma":[0.0005118723,0.001575729,0.01115322,0.00008771794,0.00008110359,0.00002649409,0.0002009739,0.000324689,0.9789109,0.004939132,0.002004154,0.0001840273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927059,0.005148472,0.0001335753,0.0002937062,0.0001004358,0.0001314603,0.00005573732,0.00001207086,0.001418589],"genre_scores_gemma":[0.9979425,0.0002518354,0.0001894785,0.00006540363,0.0001908747,0.000009442962,0.00006695812,0.00001035688,0.001273169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01672597,"threshold_uncertainty_score":0.3194947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708695410496317,"score_gpt":0.2464108758162778,"score_spread":0.2293239217113146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}