{"id":"W4396508551","doi":"10.1002/cncr.35301","title":"Langerhans cell histiocytosis: NACHO update on progress, chaos, and opportunity on the path to rational cures","year":2024,"lang":"en","type":"review","venue":"Cancer","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; National Institutes of Health; National Cancer Institute; Applebaum Foundation; Eunice Kennedy Shriver National Institute of Child Health and Human Development; St. Baldrick's Foundation; Leukemia and Lymphoma Society","keywords":"Medicine; Langerhans cell histiocytosis; Disease; Clinical trial; Histiocyte; Histiocytosis; Myeloid; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002300768,0.0008022502,0.001707892,0.002022607,0.0005201877,0.002973043,0.001088233,0.00260556,0.004787098],"category_scores_gemma":[0.003726365,0.0003092472,0.000717395,0.001444158,0.001113743,0.005119577,0.001834703,0.006173481,0.002130035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001421126,"about_ca_system_score_gemma":0.001677071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007175058,"about_ca_topic_score_gemma":0.002095083,"domain_scores_codex":[0.9993137,0.0001927378,0.00009818279,0.00008538702,0.000199582,0.000110451],"domain_scores_gemma":[0.9977663,0.00118374,0.0001871886,0.0000532829,0.0004899479,0.0003195971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003066785,0.0001278425,0.0005221925,0.006767682,0.0001018267,0.0006253194,0.0003033856,0.0004033563,0.001383782,0.01654856,0.2492379,0.7236714],"study_design_scores_gemma":[0.00002513289,0.00009764683,0.0002684526,0.002788748,0.00004634636,0.0008251772,0.0001485355,0.00008816845,0.0001479447,0.004420887,0.9911242,0.00001885959],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001999272,0.9861317,0.0002057767,0.008474241,0.003523041,0.000004624037,0.00002673383,0.00002304503,0.001410949],"genre_scores_gemma":[0.00189824,0.9798505,0.0004907426,0.00824452,0.007861734,0.00001415689,0.00009190807,0.00001415429,0.001534139],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004787098,"threshold_uncertainty_score":0.0160144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0782733883106171,"score_gpt":0.3772828131698827,"score_spread":0.2990094248592656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}