{"id":"W4396520704","doi":"10.1016/s2352-3026(24)00078-4","title":"Hydroxyurea dose optimisation for children with sickle cell anaemia in sub-Saharan Africa (REACH): extended follow-up of a multicentre, open-label, phase 1/2 trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Haematology","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sinai Health System; University of Toronto; University Health Network","funders":"National Heart, Lung, and Blood Institute; Kenya Medical Research Institute; Wellcome Trust; Cincinnati Children’s Research Foundation; Cincinnati Children's Hospital Medical Center; Bristol-Myers Squibb","keywords":"Medicine; Sickle cell anemia; Open label; Pediatrics; Anemia; Clinical trial; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004631583,0.0002095992,0.0009700148,0.0001314367,0.00006408312,0.00002650234,0.0002848254,0.0002114836,0.0000392913],"category_scores_gemma":[0.00009760184,0.0001267655,0.00007126814,0.000361447,0.0001553216,0.00008740996,0.00006431035,0.0003379887,0.00001799328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004209305,"about_ca_system_score_gemma":0.0001894498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001285319,"about_ca_topic_score_gemma":0.00008916264,"domain_scores_codex":[0.9984984,0.0001259538,0.0004357632,0.0003511222,0.0001524138,0.0004363512],"domain_scores_gemma":[0.999099,0.0002115649,0.0001350071,0.000423745,0.00004953818,0.00008118011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6760037,0.01590911,0.00210395,0.004339823,0.002730638,0.001649179,0.02131102,0.0005053034,0.03145313,0.008196139,0.1565153,0.07928272],"study_design_scores_gemma":[0.9394979,0.007391391,0.0006923071,0.001049907,0.001856449,0.0007282218,0.0007365242,0.02314157,0.01230746,0.001472337,0.0104494,0.0006765177],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848318,0.00626679,0.0002312605,0.002589967,0.0002967267,0.003824598,0.00006437323,0.00007862508,0.001815898],"genre_scores_gemma":[0.9971465,0.0009435882,0.0009068605,0.000182077,0.0001046864,0.000217466,0.0001652404,0.00004049001,0.000293046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2634943,"threshold_uncertainty_score":0.5169348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0369767541081894,"score_gpt":0.3190857287698329,"score_spread":0.2821089746616435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}