{"id":"W4396528580","doi":"10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2782","title":"Tezepelumab in Adults With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD): Efficacy and Safety From the Phase 2a COURSE Study","year":2024,"lang":"en","type":"article","venue":"","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton; McGill University Health Centre; University of Alberta","funders":"","keywords":"COPD; Pulmonary disease; Medicine; Disease; Internal medicine; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107679,0.0006678677,0.001296821,0.0001701819,0.0003252993,0.0009152251,0.0004463322,0.0006990323,0.002046287],"category_scores_gemma":[0.001359703,0.0002559986,0.001490455,0.0001771322,0.0003838483,0.000796561,0.0002218659,0.002444212,0.0004218875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005586527,"about_ca_system_score_gemma":0.0006945275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006710607,"about_ca_topic_score_gemma":0.00204446,"domain_scores_codex":[0.9996568,0.0001288386,0.00001887709,0.00005582423,0.00005229787,0.0000873809],"domain_scores_gemma":[0.9992877,0.0001891254,0.0001595222,0.00006253942,0.00006340601,0.0002378688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6291741,0.0207864,0.02391137,0.001698175,0.005283823,0.0003658695,0.0003909073,0.001969327,0.02816797,0.0004588656,0.01062679,0.2771664],"study_design_scores_gemma":[0.5954895,0.2632038,0.1181797,0.000232043,0.003446931,0.001106955,0.0002003517,0.002571381,0.00490015,0.0005619705,0.01000662,0.0001005138],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915605,0.004791467,0.0002591792,0.0004241593,0.0001059686,0.0003884919,0.0008079569,0.00005095487,0.001611337],"genre_scores_gemma":[0.9935917,0.00233704,0.0005230614,0.0008455457,0.0001386389,0.0003210288,0.001026219,0.00001580766,0.001201091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002046287,"threshold_uncertainty_score":0.006845534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273288460947407,"score_gpt":0.2996763077765429,"score_spread":0.2869434231670688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}