{"id":"W4396530381","doi":"10.1172/jci176474","title":"Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Children's Hospital Research Institute; Crohn's and Colitis Canada; Agence Nationale de la Recherche; Canadian Association of Gastroenterology","keywords":"Sting; Stimulator of interferon genes; Nociceptor; Inflammation; Dorsal root ganglion; Hyperalgesia; Nociception; Interferon; Cell biology; Medicine; Immunology; Neuroscience; Biology; Receptor; Spinal cord; Innate immune system; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003420742,0.0005856343,0.0003303618,0.0008754911,0.0002211354,0.0004443749,0.0003481441,0.0006567939,0.002324652],"category_scores_gemma":[0.0001936001,0.0003374928,0.0004482199,0.0002551078,0.0006618905,0.0003914211,0.0002648558,0.001780721,0.0005010821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005407484,"about_ca_system_score_gemma":0.0003064221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004008483,"about_ca_topic_score_gemma":0.0007645935,"domain_scores_codex":[0.9996259,0.00006867517,0.00004608083,0.00007857886,0.00006823905,0.0001124039],"domain_scores_gemma":[0.9996394,0.0000417998,0.0001364046,0.00003885173,0.00001847419,0.0001250884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006134679,0.0001870115,0.0003339645,0.00003888986,0.000008705427,0.00006718631,0.00003335903,0.00008165216,0.9968576,0.0002185777,0.00006648785,0.001493027],"study_design_scores_gemma":[0.0001994746,0.001899856,0.007504995,0.00004434512,0.00003868625,0.0004559972,0.00009450491,0.002235824,0.9850152,0.0002604576,0.002239655,0.00001110303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926649,0.001020276,0.002998336,0.0002851442,0.00005541718,0.00006011005,0.000795542,0.0002667796,0.001853487],"genre_scores_gemma":[0.9903053,0.0007325188,0.003741825,0.0001819436,0.00002235661,0.0001203748,0.0006866329,0.00007760795,0.004131568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002324652,"threshold_uncertainty_score":0.007776678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06284313801702422,"score_gpt":0.3483504577478099,"score_spread":0.2855073197307857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}