{"id":"W4396531590","doi":"10.3390/cancers16091755","title":"Activation of the Anaphase Promoting Complex Restores Impaired Mitotic Progression and Chemosensitivity in Multiple Drug-Resistant Human Breast Cancer","year":2024,"lang":"en","type":"article","venue":"Cancers","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Alberta","funders":"Canadian Cancer Society","keywords":"Cancer research; Cancer cell; Cancer; Doxorubicin; Cytotoxic T cell; Mitosis; Biology; Medicine; Internal medicine; Chemotherapy; In vitro; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001402099,0.0002920364,0.0004137813,0.0003001527,0.0001155037,0.0003161495,0.0001876596,0.0002162985,0.001269896],"category_scores_gemma":[0.000140238,0.0002008662,0.0001686926,0.0001947747,0.0001173653,0.0001291202,0.0001604536,0.000524885,0.0003077061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002619822,"about_ca_system_score_gemma":0.0001634627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008912775,"about_ca_topic_score_gemma":0.001003197,"domain_scores_codex":[0.9998553,0.00002444863,0.00002076698,0.00002609529,0.0000462262,0.00002711725],"domain_scores_gemma":[0.9998976,0.00001619733,0.00003032173,0.0000226336,0.000009066198,0.00002420329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001024461,0.00004941416,0.0001403753,0.00002156306,0.000006316199,0.00003785508,0.00001100688,0.00004686722,0.9984525,0.00005470932,0.00005257121,0.001024283],"study_design_scores_gemma":[0.00003834569,0.0008697946,0.005644488,0.000005594319,0.00002158032,0.0005282332,0.0000298051,0.000847321,0.9872707,0.0000289901,0.004709512,0.000005621809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973083,0.0009490627,0.0005039898,0.00005530401,0.00001691163,0.00002550622,0.0003392865,0.000079038,0.000722778],"genre_scores_gemma":[0.9958737,0.00076594,0.0006214818,0.00003270272,0.000007214015,0.00002555932,0.0009775616,0.00002579027,0.001669978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001269896,"threshold_uncertainty_score":0.004248261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01463065596816609,"score_gpt":0.2821085241247884,"score_spread":0.2674778681566223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}