{"id":"W4396531762","doi":"10.1038/s41588-024-01714-w","title":"Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits","year":2024,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research; McMaster University; Population Health Research Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; Medical Research Council; School of Medicine, Duke University; National Institutes of Health; Isfahan University of Medical Sciences; Brigham and Women's Hospital; British Heart Foundation; Eesti Teadusagentuur; Novo Nordisk Fonden; Israel Science Foundation; University of Oxford; King's College London; Department of Health and Social Care; U.S. Department of Veterans Affairs; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research","keywords":"Biology; Polygenic risk score; Multifactorial Inheritance; Genome-wide association study; Quantitative trait locus; Genetics; Blood pressure; Genome; Evolutionary biology; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002432212,0.0005778769,0.0006831028,0.0007222123,0.0005642341,0.0008893454,0.0002934442,0.0004455167,0.003182195],"category_scores_gemma":[0.005080948,0.0001826052,0.001189413,0.001510078,0.0002802377,0.0002549668,0.0007240139,0.0006406212,0.0005544971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001264821,"about_ca_system_score_gemma":0.0002033137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00223659,"about_ca_topic_score_gemma":0.003188474,"domain_scores_codex":[0.9982809,0.0007338042,0.0001197587,0.0005673091,0.0001774848,0.0001209205],"domain_scores_gemma":[0.9972792,0.001248886,0.0004829683,0.0005805696,0.0002207742,0.0001876868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001220393,0.0001409065,0.9489965,0.000104721,0.002389062,0.0003531785,0.0001508607,0.001067866,0.01900216,0.0001896201,0.0020835,0.02430125],"study_design_scores_gemma":[0.00006356429,0.0001314784,0.9936935,0.00001743061,0.0004612687,0.0005788257,0.00006505864,0.001865085,0.001334582,0.0003619859,0.001413929,0.00001343351],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874486,0.0006161174,0.005905652,0.0002638389,0.00003565662,0.00001935886,0.004599511,0.0001330006,0.0009782404],"genre_scores_gemma":[0.9921771,0.0001913042,0.002437123,0.0001303587,0.00004259412,0.00002325839,0.00465033,0.00002940459,0.0003184949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003182195,"threshold_uncertainty_score":0.01286292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00920210464408175,"score_gpt":0.2684908305959993,"score_spread":0.2592887259519175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}