{"id":"W4396541840","doi":"10.1158/2159-8290.cd-24-0024","title":"A Next-Generation BRAF Inhibitor Overcomes Resistance to BRAF Inhibition in Patients with <i>BRAF</i> -Mutant Cancers Using Pharmacokinetics-Informed Dose Escalation","year":2024,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Cancer Institute","keywords":"Pharmacokinetics; Mutant; Cancer research; Vemurafenib; Medicine; Pharmacology; Oncology; Internal medicine; Biology; Melanoma; Genetics; Metastatic melanoma; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007901851,0.0002341221,0.0001734636,0.0001247411,0.00007160818,0.0001927894,0.00006893599,0.0001124809,0.00001541148],"category_scores_gemma":[0.00001928851,0.0002110452,0.00005959328,0.0003248698,0.00005055371,0.0001156283,0.00005943432,0.0001100746,0.000004108691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004532524,"about_ca_system_score_gemma":0.0006056831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001403946,"about_ca_topic_score_gemma":0.002290156,"domain_scores_codex":[0.9986033,0.00003597585,0.0003009213,0.0004993294,0.0002533002,0.0003071918],"domain_scores_gemma":[0.999528,0.000008601522,0.00007757841,0.0002147534,0.00007220136,0.00009885974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005689514,0.0000553329,0.007462939,0.0002135177,0.00005040341,0.00001533285,0.0002356424,0.005398142,0.980737,0.00009379981,0.003157361,0.002011611],"study_design_scores_gemma":[0.003235813,0.0004730328,0.02123386,0.001055835,0.00008696423,0.000004422682,0.00008239084,0.002288563,0.9557177,0.00004181908,0.01496498,0.0008146149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955704,0.001025493,0.001371591,0.0001582956,0.000829743,0.000552039,0.0002400448,0.00002426082,0.0002281318],"genre_scores_gemma":[0.9973509,0.0002038292,0.0002096005,0.0005773337,0.0007374664,0.0001073326,0.0004870328,0.00004267176,0.0002838614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02501926,"threshold_uncertainty_score":0.8606174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033371768260288,"score_gpt":0.2673368469978584,"score_spread":0.2470031293152555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}