{"id":"W4396557786","doi":"10.3389/fendo.2024.1386556","title":"Effects of circulating inflammatory proteins on osteoporosis and fractures: evidence from genetic correlation and Mendelian randomization study","year":2024,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Science Foundation of Fujian Province","keywords":"Mendelian randomization; Osteoporosis; Mendelian inheritance; Medicine; Bioinformatics; Genetics; Biology; Internal medicine; Genetic variants; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03783699,0.001165564,0.002055397,0.001675859,0.0005820961,0.001377884,0.001747565,0.001969442,0.005113584],"category_scores_gemma":[0.1226902,0.0006956185,0.004284921,0.003019089,0.00236273,0.0009741775,0.001036045,0.001007156,0.0003908508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003029933,"about_ca_system_score_gemma":0.0007998648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002494306,"about_ca_topic_score_gemma":0.0009716387,"domain_scores_codex":[0.946451,0.03837539,0.003143557,0.007886556,0.003403994,0.0007396066],"domain_scores_gemma":[0.8174902,0.1477825,0.01721845,0.01352439,0.00313211,0.0008522602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02339293,0.0003244934,0.8003271,0.002777982,0.08886401,0.00271467,0.0005547656,0.001858589,0.001562006,0.009151766,0.002695404,0.06577618],"study_design_scores_gemma":[0.01105394,0.004037819,0.7989557,0.001890832,0.1086176,0.007435726,0.0004665231,0.01335629,0.001431084,0.04298877,0.009555008,0.0002108319],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8242563,0.1061415,0.05207952,0.006644766,0.001085954,0.0004482704,0.002844887,0.0004064328,0.006092255],"genre_scores_gemma":[0.9836766,0.006608117,0.007575268,0.0007359099,0.0004315313,0.000153011,0.0004955393,0.00004793777,0.0002761305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03783699,"threshold_uncertainty_score":0.2001036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006206961909458068,"score_gpt":0.2487001867479276,"score_spread":0.2424932248384695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}