{"id":"W4396559169","doi":"10.1208/s12248-024-00925-7","title":"Prediction of Individual Disease Progression Including Parameter Uncertainty in Rare Neurodegenerative Diseases: The Example of Autosomal-Recessive Spastic Ataxia Charlevoix Saguenay (ARSACS)","year":2024,"lang":"en","type":"article","venue":"The AAPS Journal","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Université de Sherbrooke","funders":"Else Kröner-Fresenius-Stiftung","keywords":"Disease; Ataxia; Medicine; Neuroscience; Pathology; Biology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005244928,0.0003146828,0.0003229064,0.0002488343,0.0004382238,0.0002499759,0.000932811,0.00004664569,0.00008159416],"category_scores_gemma":[0.002002534,0.0001713004,0.0002199253,0.0007897301,0.0006074468,0.0003788817,0.0003886733,0.0006076639,0.000007361116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006561464,"about_ca_system_score_gemma":0.0004092397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000241163,"about_ca_topic_score_gemma":0.000009177987,"domain_scores_codex":[0.9955091,0.001685178,0.0007255836,0.0005470123,0.001110218,0.0004228434],"domain_scores_gemma":[0.9972779,0.00139223,0.0004467437,0.0005062682,0.000137871,0.0002390246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001588708,0.00119796,0.05694676,0.000555505,0.0002098351,0.0006465002,0.01469208,0.06839554,0.8227795,0.001997482,0.003796365,0.02719377],"study_design_scores_gemma":[0.001970253,0.0008857579,0.4826584,0.002009516,0.000864243,0.0002347882,0.0008791787,0.05434773,0.4466648,0.008296987,0.0005943143,0.000594096],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940472,0.002344723,0.0003613609,0.000891027,0.0007696217,0.0006854098,0.0008375035,0.00004106481,0.00002214534],"genre_scores_gemma":[0.9990292,0.0002432974,0.00003208236,0.0002058603,0.0002994757,0.00008171437,0.00002009646,0.00004170527,0.00004652509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4257116,"threshold_uncertainty_score":0.6985427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06803734867148571,"score_gpt":0.3057709140100245,"score_spread":0.2377335653385388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}