{"id":"W4396576324","doi":"10.1161/circinterventions.124.014054","title":"Angiogenic Gene Therapy for Refractory Angina: Results of the EXACT Phase 2 Trial","year":2024,"lang":"en","type":"article","venue":"Circulation Cardiovascular Interventions","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Duke Clinical Research Institute; Clinical and Translational Science Institute, University of Florida; National Institutes of Health; Ionis Pharmaceuticals; AstraZeneca; CSL Behring; Amgen; National Heart, Lung, and Blood Institute; Pfizer; U.S. Department of Defense; Sanofi; American Heart Association; Gilead Sciences","keywords":"Medicine; Adverse effect; Refractory (planetary science); Angina; Internal medicine; Cardiology; Canadian Cardiovascular Society; Surgery; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002079288,0.0007313897,0.001172346,0.0002249455,0.0001403889,0.0006702907,0.00027891,0.0007653247,0.002430971],"category_scores_gemma":[0.001139073,0.0001394023,0.0008752967,0.0001964571,0.0004240062,0.0005205746,0.0001786707,0.000975786,0.0002688755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003520945,"about_ca_system_score_gemma":0.000462249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002535368,"about_ca_topic_score_gemma":0.0005790637,"domain_scores_codex":[0.9995801,0.0002275996,0.00002538329,0.00004147601,0.00005947127,0.00006598054],"domain_scores_gemma":[0.9995414,0.0001554533,0.0001158496,0.0000309301,0.00003692428,0.0001194983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7878398,0.01086351,0.009769881,0.002071326,0.003522476,0.0003861722,0.0001840636,0.002206688,0.01731651,0.0009061585,0.005997119,0.1589364],"study_design_scores_gemma":[0.8109676,0.1578606,0.02100089,0.0002097392,0.001664859,0.0004053592,0.00005700767,0.00126084,0.001297329,0.0005057278,0.004735183,0.00003484829],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848487,0.01004346,0.0003834558,0.0007649426,0.0001768796,0.0006102081,0.0006056956,0.00003709536,0.002529566],"genre_scores_gemma":[0.9858393,0.006333327,0.001023928,0.001522999,0.0005255821,0.001158323,0.001436822,0.00001846488,0.002141275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002430971,"threshold_uncertainty_score":0.01099646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05935458877020194,"score_gpt":0.3639839894957784,"score_spread":0.3046294007255765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}