{"id":"W4396576324","doi":"10.1161/circinterventions.124.014054","title":"Angiogenic Gene Therapy for Refractory Angina: Results of the EXACT Phase 2 Trial","year":2024,"lang":"en","type":"article","venue":"Circulation Cardiovascular Interventions","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Duke Clinical Research Institute; Clinical and Translational Science Institute, University of Florida; National Institutes of Health; Ionis Pharmaceuticals; AstraZeneca; CSL Behring; Amgen; National Heart, Lung, and Blood Institute; Pfizer; U.S. Department of Defense; Sanofi; American Heart Association; Gilead Sciences","keywords":"Medicine; Adverse effect; Refractory (planetary science); Angina; Internal medicine; Cardiology; Canadian Cardiovascular Society; Surgery; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001255996,0.0001482795,0.0002169646,0.0001235029,0.0001241782,0.00004477366,0.0002747564,0.0001357884,0.00002731437],"category_scores_gemma":[0.0001647735,0.0001206766,0.00411856,0.0002946195,0.00008938465,0.00001049007,0.00005538234,0.00009584753,0.000006437687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000455822,"about_ca_system_score_gemma":0.0001519905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001027642,"about_ca_topic_score_gemma":0.00001324061,"domain_scores_codex":[0.9983267,0.0002963539,0.0004320653,0.000422275,0.000317397,0.0002052015],"domain_scores_gemma":[0.9986619,0.00003574413,0.00008036612,0.0009655539,0.0002084905,0.00004788998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03032929,0.000785996,0.00003100613,0.0002441677,0.008923876,0.000004612369,0.0001425124,0.005127965,0.841046,0.0001192455,0.004791125,0.1084542],"study_design_scores_gemma":[0.08302622,0.007235007,0.001178568,0.0002777451,0.000774339,0.00003797135,0.00006077169,0.001463591,0.6517014,0.0003926179,0.2532949,0.0005568961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9218771,0.05072298,0.02406003,0.0001370769,0.0009218301,0.00171041,0.0004000526,0.00003499469,0.0001354903],"genre_scores_gemma":[0.9977199,0.0004891646,0.00008245246,0.00002029928,0.0005946063,0.0002543717,0.0004534337,0.00004398176,0.0003418079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2485038,"threshold_uncertainty_score":0.4921047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05935458877020194,"score_gpt":0.3639839894957784,"score_spread":0.3046294007255765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}