{"id":"W4396581535","doi":"10.1021/acsinfecdis.4c00157","title":"Polyamine-Mediated Sensitization of <i>Klebsiella pneumoniae</i> to Macrolides through a Dual Mode of Action","year":2024,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Saskatchewan Health Research Foundation; University of Regina","keywords":"Klebsiella pneumoniae; Mode of action; Sensitization; Microbiology; Dual (grammatical number); Action (physics); Biology; Chemistry; Immunology; Toxicology; Biochemistry; Escherichia coli; Physics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001512522,0.0003878963,0.0002598309,0.0001156387,0.00009148405,0.0002685566,0.0003311406,0.000336264,0.00191267],"category_scores_gemma":[0.0001187208,0.0001661528,0.0002295095,0.0001334136,0.0001544226,0.000197004,0.00020099,0.0003564826,0.0006317009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002352183,"about_ca_system_score_gemma":0.0001556098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006948608,"about_ca_topic_score_gemma":0.001603223,"domain_scores_codex":[0.9998094,0.00002335983,0.00002013515,0.00005574188,0.00004819648,0.00004321512],"domain_scores_gemma":[0.9998943,0.0000206478,0.00003252381,0.00001177868,0.00002298397,0.00001769893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003232059,0.000006248828,0.00002471547,0.00001654948,0.000001004519,0.000008018438,0.000003130951,0.00001285391,0.9995554,0.000009807096,0.00001515739,0.0003148339],"study_design_scores_gemma":[0.000001830315,0.0001029,0.0005540524,0.000001321013,0.000002085445,0.0000259041,0.000004256853,0.0001558634,0.9986784,0.000002975835,0.0004686166,0.000001779832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986486,0.000924223,0.006470695,0.0001375894,0.00004051187,0.0001027719,0.0009174348,0.0002770922,0.004643812],"genre_scores_gemma":[0.9738058,0.001249295,0.01556458,0.0001760713,0.00001129649,0.0001370405,0.001500502,0.00009885071,0.007456576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00191267,"threshold_uncertainty_score":0.006398559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008038568429690304,"score_gpt":0.2893153905620097,"score_spread":0.2812768221323194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}