{"id":"W4396585099","doi":"10.1161/circulationaha.123.065304","title":"Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension","year":2024,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; National Natural Science Foundation of China; National Key Research and Development Program of China; U.S. Department of Veterans Affairs; American Thoracic Society; American Heart Association","keywords":"Medicine; Deubiquitinating enzyme; Protein kinase B; Ubiquitin; Pulmonary artery; Pulmonary hypertension; Knockout mouse; AKT1; Internal medicine; Endocrinology; Pathology; Signal transduction; Biology; Cell biology; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002202823,0.0004909037,0.0004389271,0.0004172285,0.0002093481,0.0003184094,0.0004303667,0.0004303415,0.002466994],"category_scores_gemma":[0.0002258677,0.000185728,0.00031172,0.0002402057,0.0004007125,0.0002486219,0.0002405603,0.0008309453,0.0005025783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002785444,"about_ca_system_score_gemma":0.0002620484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000512231,"about_ca_topic_score_gemma":0.0006941913,"domain_scores_codex":[0.9997885,0.00003171307,0.00003485352,0.00004816693,0.00005311481,0.0000437685],"domain_scores_gemma":[0.9996753,0.00004401006,0.0001151721,0.00003245785,0.00002205477,0.0001111147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007532084,0.0002119867,0.0003258692,0.00004666808,0.00001663921,0.0000434187,0.00001418024,0.00007734273,0.9960114,0.00005399696,0.00005624571,0.002388971],"study_design_scores_gemma":[0.0001784784,0.002187137,0.006454287,0.00001060178,0.00007572531,0.0002986139,0.00003045724,0.000905051,0.9880137,0.00005020761,0.001787898,0.000007833497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963779,0.0009607248,0.001398762,0.0001057378,0.00004036175,0.00002738829,0.0003510043,0.0001536474,0.0005844716],"genre_scores_gemma":[0.9958358,0.000551088,0.001007181,0.00004680992,0.00001398667,0.00004772206,0.0004470951,0.00002890081,0.002021425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002466994,"threshold_uncertainty_score":0.008252978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0321961869358551,"score_gpt":0.2802348822458726,"score_spread":0.2480386953100175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}