{"id":"W4396585731","doi":"10.1021/acs.molpharmaceut.3c01169","title":"Biodistribution of Native and Nanoformulated Innate Defense Regulator Peptide 1002","year":2024,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Lundbeckfonden; Canada Research Chairs; Michael Smith Health Research BC; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada","keywords":"Biodistribution; Pharmacology; Pharmacokinetics; Biocompatibility; Chemistry; Peptide; Bioavailability; Biochemistry; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395856,0.0001586191,0.0001991641,0.0001040591,0.00008399062,0.00002506119,0.00007575924,0.0001480751,0.0001110815],"category_scores_gemma":[0.00002373623,0.0001454336,0.00008507791,0.0001763657,0.000303269,0.00009116648,0.00008611625,0.0002216344,0.00005267022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003199982,"about_ca_system_score_gemma":0.00004452533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002211198,"about_ca_topic_score_gemma":0.000001106689,"domain_scores_codex":[0.9992139,0.00008040355,0.000217037,0.0002180872,0.0000340993,0.0002364269],"domain_scores_gemma":[0.9996856,0.00004887961,0.00006022255,0.0001115895,0.00007098251,0.00002271555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005823445,0.00003458156,0.00006947304,0.000108087,0.0002762466,0.00003146133,0.000281573,0.00001674319,0.9887243,0.005357311,0.001362697,0.0036793],"study_design_scores_gemma":[0.0004384276,0.00005921098,0.0001075182,0.00008931418,0.0001218494,0.00009391245,0.00008659734,0.0002928717,0.9554219,0.0003720621,0.04275711,0.0001592234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881169,0.00887324,0.001266003,0.0002498065,0.0003571295,0.0001726362,0.0002359739,0.00009429323,0.0006340237],"genre_scores_gemma":[0.9984636,0.0003274032,0.0001075442,0.0001429402,0.00001069312,0.000003383203,0.0001360747,0.00001818477,0.0007902067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04139441,"threshold_uncertainty_score":0.5930611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0147533143467584,"score_gpt":0.2728019156062073,"score_spread":0.2580486012594489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}