{"id":"W4396585731","doi":"10.1021/acs.molpharmaceut.3c01169","title":"Biodistribution of Native and Nanoformulated Innate Defense Regulator Peptide 1002","year":2024,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia; Lundbeckfonden; Canada Research Chairs; Michael Smith Health Research BC; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada","keywords":"Biodistribution; Pharmacology; Pharmacokinetics; Biocompatibility; Chemistry; Peptide; Bioavailability; Biochemistry; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002632597,0.0002615868,0.0001569084,0.0001395458,0.00006567943,0.0002214742,0.0001317659,0.0002553132,0.00035917],"category_scores_gemma":[0.0001475004,0.00007932624,0.0001451443,0.0001139253,0.0002069212,0.000266832,0.0001128853,0.0003327102,0.0001142241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002730974,"about_ca_system_score_gemma":0.0001570816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000759583,"about_ca_topic_score_gemma":0.0006252546,"domain_scores_codex":[0.999916,0.00001162394,0.00000698962,0.0000238073,0.00002188265,0.00001963966],"domain_scores_gemma":[0.9999025,0.00002717517,0.00002504652,0.000006791183,0.0000221782,0.00001629089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005999116,0.00001525506,0.0000956831,0.00002022051,0.000002345234,0.00002036007,0.00001619062,0.0001182903,0.998984,0.00003445331,0.00001508211,0.0006180703],"study_design_scores_gemma":[0.000007641516,0.0006279101,0.002032221,0.000004886794,0.00001148395,0.00006908095,0.00002755582,0.002589968,0.9939732,0.0000174687,0.0006322118,0.000006463932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972486,0.0004817825,0.00169762,0.00001969948,0.00001141947,0.00001088419,0.0001209904,0.00002778168,0.0003811617],"genre_scores_gemma":[0.9931574,0.0005311607,0.004163498,0.0000351228,0.000007340321,0.0000373434,0.0002815858,0.00002047816,0.001766111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000759583,"threshold_uncertainty_score":0.001981437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0147533143467584,"score_gpt":0.2728019156062073,"score_spread":0.2580486012594489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}