{"id":"W4396587176","doi":"10.1158/1538-7445.sabcs23-ps14-08","title":"Abstract PS14-08: Safety evaluation from the KEYNOTE-355 study of pembrolizumab plus chemotherapy vs placebo plus chemotherapy in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pembrolizumab; Chemotherapy; Oncology; Internal medicine; Breast cancer; Placebo; Triple-negative breast cancer; Metastatic breast cancer; Recurrent breast cancer; Cancer; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002837802,0.001017687,0.001633516,0.0003252705,0.0003462784,0.0008733073,0.0008483031,0.001218613,0.009665021],"category_scores_gemma":[0.002252669,0.0004264598,0.001981487,0.0004393035,0.0006270428,0.0008294825,0.0004036429,0.002350581,0.001177747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009638108,"about_ca_system_score_gemma":0.001543606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005370777,"about_ca_topic_score_gemma":0.001652688,"domain_scores_codex":[0.9990544,0.0005783665,0.00008178668,0.0001256019,0.00008665806,0.00007315484],"domain_scores_gemma":[0.9988772,0.000229546,0.0004540848,0.00009997834,0.0001034157,0.0002358742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9222563,0.006722324,0.00255143,0.002209782,0.002950057,0.0000833762,0.0001149947,0.0007877442,0.01114295,0.0002790654,0.003561078,0.04734098],"study_design_scores_gemma":[0.7007799,0.2770139,0.01135095,0.0001935173,0.002871338,0.0002046109,0.0000557198,0.0006676074,0.002121308,0.0003008791,0.004410951,0.00002939671],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735685,0.007211789,0.001509195,0.001078139,0.0003106482,0.005390964,0.004915017,0.0002187681,0.005796955],"genre_scores_gemma":[0.9859446,0.00256828,0.001346037,0.001320194,0.0002816325,0.002836769,0.003110605,0.00002571749,0.002566231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009665021,"threshold_uncertainty_score":0.03233266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05802591239139755,"score_gpt":0.3928854851214807,"score_spread":0.3348595727300832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}