{"id":"W4396587235","doi":"10.1158/1538-7445.sabcs23-ps16-03","title":"Abstract PS16-03: Intratumoral dosing of INT230-6 in Early-Stage Breast Cancer Patients Induces Tumor Cell Necrosis and Immunomodulatory Effects: A Phase II Randomized Window-Of-Opportunity Study – the INVINCIBLE Trial","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University; Ontario Institute for Cancer Research; Institute of Cancer Research; Ottawa Hospital","funders":"","keywords":"Medicine; Breast cancer; Randomized controlled trial; Stage (stratigraphy); Dosing; Cancer; Necrosis; Window of opportunity; Oncology; Internal medicine; Therapeutic window; Pathology; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00115538,0.001325855,0.001254602,0.0002917119,0.000257986,0.0008837491,0.0006820114,0.001158539,0.005433649],"category_scores_gemma":[0.0006096773,0.0003701217,0.001116009,0.0003047841,0.0008192144,0.0008269429,0.0002573225,0.003345378,0.0009507544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007593901,"about_ca_system_score_gemma":0.001308928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005207215,"about_ca_topic_score_gemma":0.001221606,"domain_scores_codex":[0.9997131,0.0001322613,0.00001506832,0.00005244486,0.0000310979,0.00005602627],"domain_scores_gemma":[0.999553,0.00007255754,0.0001144521,0.00004564226,0.00002647084,0.0001878238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8282757,0.04685773,0.001653458,0.0008925764,0.000756228,0.0001280467,0.0001264021,0.001138653,0.04829849,0.0003797519,0.003121725,0.06837128],"study_design_scores_gemma":[0.5967581,0.3892167,0.00332958,0.00004475251,0.0003369346,0.0001492577,0.00004441263,0.000678607,0.006610424,0.0003759171,0.00242951,0.00002572441],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916406,0.002213531,0.0004862492,0.0005061901,0.000157846,0.001909337,0.0009881536,0.0001079569,0.001990214],"genre_scores_gemma":[0.9880852,0.001732151,0.001357835,0.0006974256,0.0001945875,0.002201532,0.001248421,0.0000355199,0.004447265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005433649,"threshold_uncertainty_score":0.01817739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08482277067803398,"score_gpt":0.436833172211823,"score_spread":0.352010401533789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}