{"id":"W4396587274","doi":"10.1158/1538-7445.sabcs23-po5-27-05","title":"Abstract PO5-27-05: Computational design and validation of a novel peptide-drug conjugate for treatment of triple negative breast cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"ProteinQure (Canada)","funders":"","keywords":"Triple-negative breast cancer; Conjugate; Medicine; Breast cancer; Drug; Cancer; Oncology; Peptide; Internal medicine; Pharmacology; Chemistry; Mathematics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003935184,0.0005462257,0.0007661566,0.00028166,0.0002569511,0.0005840865,0.0007273362,0.0007967603,0.005147651],"category_scores_gemma":[0.0006594399,0.0002913812,0.0004861738,0.0001852494,0.0002774722,0.0002476602,0.0003337334,0.0004830143,0.0004302194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000589968,"about_ca_system_score_gemma":0.001424797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003354697,"about_ca_topic_score_gemma":0.004280714,"domain_scores_codex":[0.9999205,0.00002333359,0.00000310477,0.0000152597,0.00001759962,0.00002021065],"domain_scores_gemma":[0.9997804,0.0001288283,0.00001336059,0.00001012886,0.00004799492,0.00001927936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002369728,0.0001377225,0.001839099,0.0002259581,0.00005509685,0.000190109,0.00002661019,0.9758085,0.003636134,0.002006984,0.001793888,0.01404304],"study_design_scores_gemma":[0.00006098174,0.0001351684,0.0001775219,0.000006848437,0.00001424679,0.00001639915,0.000018331,0.996777,0.001388687,0.0003150961,0.001085986,0.000003682825],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8748616,0.0009793051,0.08806263,0.0009959518,0.0002536795,0.0003904811,0.00180198,0.001544771,0.03110955],"genre_scores_gemma":[0.9250931,0.0002274642,0.06809304,0.0002737347,0.00001867023,0.000375871,0.001142657,0.0001442698,0.004631348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005147651,"threshold_uncertainty_score":0.01722068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1282613769034948,"score_gpt":0.4268134203051029,"score_spread":0.298552043401608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}