{"id":"W4396587344","doi":"10.1158/1538-7445.sabcs23-po4-19-05","title":"Abstract PO4-19-05: OptimICE-pCR: De-escalation of therapy in early-stage TNBC patients who achieve pCR after neoadjuvant chemotherapy with checkpoint inhibitor therapy (Alliance A012103)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Medical Imaging Techniques and Applications","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Oncology; Chemotherapy; Stage (stratigraphy); Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000796913,0.0004254601,0.0006818622,0.0002497485,0.0001801061,0.0006081785,0.0005002631,0.0004690764,0.009034361],"category_scores_gemma":[0.0006596835,0.0001358157,0.0006740768,0.00017122,0.0002577758,0.0003976486,0.0003405331,0.001730145,0.001254137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004855977,"about_ca_system_score_gemma":0.001149938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002074491,"about_ca_topic_score_gemma":0.0005953756,"domain_scores_codex":[0.9997645,0.00008999856,0.00001407557,0.00004763751,0.00003223641,0.00005165375],"domain_scores_gemma":[0.9996401,0.00006155021,0.00007035016,0.00003017375,0.00002758172,0.0001703054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2100392,0.02638344,0.01411849,0.001207059,0.0005898333,0.0003793808,0.0001084561,0.004675806,0.0547934,0.001354997,0.02479545,0.6615545],"study_design_scores_gemma":[0.3315393,0.4758559,0.05788732,0.0004345878,0.001532035,0.002063733,0.0001315724,0.01553233,0.05479084,0.002654437,0.05748531,0.00009263971],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684684,0.0046488,0.005007834,0.002426751,0.0004657416,0.003056589,0.001920072,0.0005535915,0.01345217],"genre_scores_gemma":[0.9671392,0.002169849,0.01090041,0.00176022,0.0003017628,0.002821207,0.003064356,0.00008693346,0.01175615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009034361,"threshold_uncertainty_score":0.03022295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05608263485014749,"score_gpt":0.3994014216998233,"score_spread":0.3433187868496759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}