{"id":"W4396587344","doi":"10.1158/1538-7445.sabcs23-po4-19-05","title":"Abstract PO4-19-05: OptimICE-pCR: De-escalation of therapy in early-stage TNBC patients who achieve pCR after neoadjuvant chemotherapy with checkpoint inhibitor therapy (Alliance A012103)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Medical Imaging Techniques and Applications","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Oncology; Chemotherapy; Stage (stratigraphy); Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009029723,0.0002169978,0.0003452566,0.0002401574,0.00006256322,0.00006896452,0.0002349765,0.0001606715,0.0005973452],"category_scores_gemma":[0.00003870759,0.0001570943,0.0000947575,0.0007992187,0.0003244679,0.0001677253,0.00004127876,0.000934217,0.00001302697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004125561,"about_ca_system_score_gemma":0.0005381493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001181705,"about_ca_topic_score_gemma":0.00003829079,"domain_scores_codex":[0.9975565,0.0000813756,0.0004285747,0.000517967,0.000863401,0.0005521841],"domain_scores_gemma":[0.9987327,0.0001206449,0.00007485347,0.0004965654,0.0003097743,0.0002654544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01253113,0.002867214,0.2718566,0.00159965,0.0003755792,0.0003215261,0.009294402,0.00007257464,0.2233568,0.0005280148,0.02703341,0.4501631],"study_design_scores_gemma":[0.005463066,0.001966197,0.7891443,0.003478815,0.00001282229,0.000006130131,0.0001347092,0.001736535,0.1405361,0.0004683444,0.05663203,0.0004208711],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985504,0.002150502,0.0004430334,0.009576626,0.00005181444,0.001683288,0.00004996502,0.0001020248,0.0004386852],"genre_scores_gemma":[0.9823731,0.01258921,0.002030096,0.0006421011,0.0002222691,0.001131801,0.0000297357,0.00007827819,0.0009034405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5172877,"threshold_uncertainty_score":0.6540511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05608263485014749,"score_gpt":0.3994014216998233,"score_spread":0.3433187868496759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}