{"id":"W4396587404","doi":"10.1158/1538-7445.sabcs23-po2-25-01","title":"Abstract PO2-25-01: Tumor Derived Chitinase-3 like 1 Induces Neutrophil Extracellular Traps that Promote T cell Exclusion and Resistance to Immunotherapies in Breast Cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Neutrophil extracellular traps; Chitinase; Cancer; Extracellular; Breast cancer; Medicine; Immunology; Cancer research; Internal medicine; Biology; Inflammation; Enzyme; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001495006,0.0003412324,0.0003021674,0.0002290297,0.0001287022,0.0002641905,0.0002239728,0.0004025453,0.002192519],"category_scores_gemma":[0.0000898921,0.0001239417,0.0002930748,0.0001501113,0.0002499598,0.0001451937,0.0001778574,0.001322056,0.0006673189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002717561,"about_ca_system_score_gemma":0.0002875315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006552722,"about_ca_topic_score_gemma":0.0008339035,"domain_scores_codex":[0.9998299,0.00002838275,0.00001386755,0.00002665947,0.00004082044,0.00006049925],"domain_scores_gemma":[0.9998801,0.00001838228,0.00002916668,0.00001432216,0.000009511698,0.00004850635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003836066,0.0002043323,0.000107016,0.00003121556,0.000005002255,0.00006202725,0.0000101443,0.00005617012,0.9979632,0.00005264631,0.0001516021,0.0009731393],"study_design_scores_gemma":[0.0001643484,0.00367318,0.005042283,0.00001081888,0.00001775141,0.0004096002,0.00005401483,0.001100811,0.9867431,0.00007071719,0.002706824,0.000006473962],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9942321,0.001023399,0.001486415,0.0003019097,0.00009196598,0.00007905569,0.0008737184,0.0001197058,0.00179175],"genre_scores_gemma":[0.9932131,0.0003851017,0.00104698,0.0001467454,0.00001939158,0.00009425934,0.001009573,0.00001999334,0.004064826],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002192519,"threshold_uncertainty_score":0.007334709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.038245905195956,"score_gpt":0.3148035291024407,"score_spread":0.2765576239064848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}