{"id":"W4396587639","doi":"10.1158/1538-7445.sabcs23-po2-20-04","title":"Abstract PO2-20-04: TACTIVE-U: phase 1b/2 umbrella study of vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) estrogen receptor (ER) degrader, combined with other anticancer treatments in ER–positive advanced or metastatic breast cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Ottawa Hospital; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Chimera (genetics); Proteolysis; Estrogen receptor; Medicine; Cancer research; Estrogen; Internal medicine; Chemistry; Cancer; Biochemistry; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007066581,0.0006933752,0.001321092,0.0008143085,0.0002250333,0.00008974851,0.0003678817,0.0001249557,0.001870187],"category_scores_gemma":[0.00006413538,0.0004884922,0.0001764221,0.002737592,0.0005374353,0.0005848879,0.00008992331,0.001233238,0.0000237705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001849707,"about_ca_system_score_gemma":0.002149322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005341028,"about_ca_topic_score_gemma":0.001264665,"domain_scores_codex":[0.994407,0.0004096084,0.0008620129,0.001389224,0.001625076,0.001307097],"domain_scores_gemma":[0.997547,0.0004138882,0.0002638632,0.0006571481,0.0007250916,0.0003930025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1042698,0.01688034,0.02312871,0.002884859,0.007917482,0.001390761,0.01459622,0.0008993165,0.5770343,0.0000580724,0.0001424009,0.2507977],"study_design_scores_gemma":[0.2183311,0.04183406,0.08713567,0.03253965,0.003887197,0.0004725412,0.04203966,0.001484626,0.5626794,0.0003109002,0.005352286,0.003932838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774241,0.01182915,0.00007109984,0.001121132,0.0001500897,0.007913413,0.001238783,0.0001243586,0.0001278425],"genre_scores_gemma":[0.9892557,0.001153416,0.001042856,0.00006001327,0.0002262022,0.007114566,0.00005777075,0.000260411,0.0008290629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2468649,"threshold_uncertainty_score":0.9997567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06529943656489028,"score_gpt":0.4349569742338259,"score_spread":0.3696575376689356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}