{"id":"W4396587639","doi":"10.1158/1538-7445.sabcs23-po2-20-04","title":"Abstract PO2-20-04: TACTIVE-U: phase 1b/2 umbrella study of vepdegestrant, a PROteolysis TArgeting Chimera (PROTAC) estrogen receptor (ER) degrader, combined with other anticancer treatments in ER–positive advanced or metastatic breast cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; Ottawa Hospital; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Chimera (genetics); Proteolysis; Estrogen receptor; Medicine; Cancer research; Estrogen; Internal medicine; Chemistry; Cancer; Biochemistry; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001654101,0.001624896,0.00130579,0.000569985,0.0005566974,0.001661149,0.001364638,0.001738446,0.006477545],"category_scores_gemma":[0.0004824309,0.0005247716,0.0009552253,0.0004835305,0.0009342239,0.001055975,0.0003340097,0.004292474,0.002217339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00142112,"about_ca_system_score_gemma":0.001405452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001643165,"about_ca_topic_score_gemma":0.00340635,"domain_scores_codex":[0.9995371,0.0001820607,0.0000189581,0.00007421483,0.00006371629,0.0001239095],"domain_scores_gemma":[0.9996146,0.00003044114,0.00005646297,0.00005297866,0.000025678,0.0002199065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1924117,0.124428,0.004303892,0.0009899281,0.001278238,0.0006732631,0.0003652524,0.003726932,0.4439598,0.001642258,0.0281729,0.1980479],"study_design_scores_gemma":[0.2283687,0.598747,0.01781224,0.0001047856,0.0009668681,0.001916939,0.0001555702,0.005907436,0.1141218,0.0006423318,0.03116509,0.00009132986],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736616,0.005098771,0.002255434,0.00117671,0.0003135368,0.002858962,0.00391706,0.0007184994,0.00999955],"genre_scores_gemma":[0.9664665,0.002579588,0.00422433,0.001475534,0.0002320149,0.002395213,0.008295237,0.0001517015,0.0141798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006477545,"threshold_uncertainty_score":0.02166951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06529943656489028,"score_gpt":0.4349569742338259,"score_spread":0.3696575376689356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}