{"id":"W4396588053","doi":"10.1158/1538-7445.sabcs23-po2-08-07","title":"Abstract PO2-08-07: Evaluating chemotherapy receipt and candidacy for PARP inhibitors in germline BRCA1/2 carriers with early and locally advanced breast cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Candidacy; Germline; Oncology; Medicine; Receipt; Breast cancer; Internal medicine; Chemotherapy; Cancer; Biology; Genetics; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001257653,0.0001632812,0.0002441278,0.0008527361,0.0002365459,0.0004488048,0.000443255,0.0003198445,0.001519168],"category_scores_gemma":[0.003087225,0.0001494593,0.0002403553,0.0008020332,0.0002426084,0.0003486443,0.0003194718,0.0002904265,0.0002989398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006182457,"about_ca_system_score_gemma":0.0006681224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002935775,"about_ca_topic_score_gemma":0.00390407,"domain_scores_codex":[0.9994364,0.0001779005,0.0001098725,0.0001063608,0.00009783236,0.00007158933],"domain_scores_gemma":[0.996618,0.000634685,0.002059216,0.00005735574,0.0002689662,0.0003617352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002174393,0.0000262659,0.998485,0.00001120332,0.00001069414,0.00005580625,0.00001740302,0.00003071029,0.000135731,0.000003274571,0.0000749773,0.000931552],"study_design_scores_gemma":[0.00001559001,0.0004133047,0.9980671,0.00001007586,0.000030662,0.0004880569,0.0001124858,0.0002189269,0.0003624901,0.000006812144,0.0002723256,0.000002291425],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999095,0.0001366411,0.00004547882,0.00002247053,0.000002435531,0.00002436721,0.0003977554,0.000002744087,0.000273176],"genre_scores_gemma":[0.9991698,0.00006542386,0.0001377068,0.00002287509,0.000006513348,0.00002447347,0.0004623871,0.000002420414,0.0001083745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002935775,"threshold_uncertainty_score":0.006651223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03062042304810058,"score_gpt":0.4033620712767669,"score_spread":0.3727416482286663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}