{"id":"W4396588255","doi":"10.1158/1538-7445.sabcs23-gs01-10","title":"Abstract GS01-10: HER2CLIMB-02: Randomized, Double-Blind Phase 3 Trial of Tucatinib and Trastuzumab Emtansine for Previously Treated HER2-Positive Metastatic Breast Cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta","funders":"","keywords":"Trastuzumab emtansine; Medicine; Metastatic breast cancer; Oncology; Internal medicine; Breast cancer; Trastuzumab; Cancer; Double blind; Randomized controlled trial; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002255073,0.002360389,0.003117811,0.000573257,0.0006881177,0.00156171,0.001317014,0.002205198,0.01323074],"category_scores_gemma":[0.001317888,0.001078028,0.001558716,0.0005542519,0.001723455,0.001247692,0.0004629629,0.004287791,0.002542916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001116946,"about_ca_system_score_gemma":0.002384078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001389089,"about_ca_topic_score_gemma":0.004706447,"domain_scores_codex":[0.9993008,0.0003368169,0.00003491821,0.000137618,0.00005379791,0.0001359508],"domain_scores_gemma":[0.9991505,0.0001363857,0.00013908,0.00005875842,0.00005653092,0.0004586712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9793762,0.008771973,0.0002852231,0.0003167186,0.0004097311,0.00003716952,0.0000282289,0.0002621973,0.002817643,0.00009300717,0.001471203,0.006130754],"study_design_scores_gemma":[0.9677868,0.03074584,0.0005362264,0.00001057601,0.00008979761,0.0000175362,0.00000662173,0.0001966642,0.0001654442,0.00006689292,0.0003699086,0.000007594183],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647401,0.003617264,0.001052025,0.001468343,0.001163784,0.01748118,0.004459288,0.0006023156,0.005415699],"genre_scores_gemma":[0.9652495,0.002021361,0.001855636,0.002810863,0.0007297273,0.01459103,0.003390145,0.00007544395,0.009276239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01323074,"threshold_uncertainty_score":0.04426122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1888228164544587,"score_gpt":0.5289525704182272,"score_spread":0.3401297539637685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}