{"id":"W4396588255","doi":"10.1158/1538-7445.sabcs23-gs01-10","title":"Abstract GS01-10: HER2CLIMB-02: Randomized, Double-Blind Phase 3 Trial of Tucatinib and Trastuzumab Emtansine for Previously Treated HER2-Positive Metastatic Breast Cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta","funders":"","keywords":"Trastuzumab emtansine; Medicine; Metastatic breast cancer; Oncology; Internal medicine; Breast cancer; Trastuzumab; Cancer; Double blind; Randomized controlled trial; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.005824392,0.0004796271,0.001750943,0.0008893451,0.0002318239,0.0002437983,0.0003561414,0.0002232272,0.004701992],"category_scores_gemma":[0.00061492,0.0003679834,0.0004528984,0.001580067,0.001317776,0.0002521254,0.0001219193,0.001176953,0.00003715152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001210739,"about_ca_system_score_gemma":0.005375626,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007049195,"about_ca_topic_score_gemma":0.0009949997,"domain_scores_codex":[0.9938933,0.0006009088,0.001163917,0.001146373,0.001836809,0.001358666],"domain_scores_gemma":[0.9935009,0.003246753,0.0001669457,0.000647446,0.00173068,0.0007073084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9050509,0.001164348,0.00002373762,0.004983843,0.001715589,0.0002092695,0.001560966,0.00001203182,0.009031756,0.0001674918,0.01096278,0.06511723],"study_design_scores_gemma":[0.958065,0.003657002,0.0001262617,0.004795155,0.0009552456,0.0001065472,0.0004446626,0.0008405852,0.02499494,0.0001981032,0.005405298,0.0004111626],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9401313,0.02803141,0.00008443317,0.007443706,0.0005031127,0.01891281,0.002538784,0.0001195689,0.002234861],"genre_scores_gemma":[0.9688291,0.01062579,0.0001530101,0.00006663075,0.001219906,0.01115921,0.0002040897,0.0001992292,0.007543057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06470607,"threshold_uncertainty_score":0.9998772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1888228164544587,"score_gpt":0.5289525704182272,"score_spread":0.3401297539637685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}