{"id":"W4396590627","doi":"10.1158/1538-7445.sabcs23-lbo1-04","title":"Abstract LBO1-04: Primary results from a phase 2a study of zanidatamab (zani) + palbociclib (palbo) + fulvestrant (fulv) in HER2+/HR+ metastatic breast cancer (mBC)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Baker Hughes (Canada); Health Sciences Centre; Zymeworks (Canada); Ottawa Hospital; Jewish General Hospital","funders":"","keywords":"Palbociclib; Fulvestrant; Metastatic breast cancer; Medicine; Oncology; Internal medicine; Breast cancer; Cancer; Gynecology; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001688389,0.0005323036,0.001176841,0.0008605869,0.0001416618,0.0001272948,0.0006416549,0.0001571086,0.002003639],"category_scores_gemma":[0.0001602811,0.0004530109,0.0001795326,0.002130188,0.0005006033,0.0005593253,0.0002423196,0.001857345,0.00007348002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001681016,"about_ca_system_score_gemma":0.002505337,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03257549,"about_ca_topic_score_gemma":0.007913301,"domain_scores_codex":[0.9935403,0.0003809299,0.001209467,0.001501798,0.002120306,0.001247133],"domain_scores_gemma":[0.9966918,0.0007981061,0.0002013614,0.001289609,0.0005613017,0.0004578503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.04072535,0.01044898,0.008674921,0.003699615,0.003054776,0.005563894,0.02186717,0.0006479814,0.4336855,0.00008759911,0.004832897,0.4667113],"study_design_scores_gemma":[0.1303418,0.00703197,0.7158549,0.0199146,0.001393061,0.0003874631,0.03197747,0.001161982,0.0462409,0.001959125,0.04099435,0.002742322],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712396,0.0151769,0.00003569042,0.003511989,0.0004491406,0.002480909,0.006459786,0.0001497588,0.0004962378],"genre_scores_gemma":[0.9950115,0.001726648,0.0002479104,0.0001664888,0.000674953,0.001044936,0.0002845219,0.0001734483,0.0006695885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.70718,"threshold_uncertainty_score":0.9997922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1094288892429852,"score_gpt":0.4624104369764118,"score_spread":0.3529815477334266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}