{"id":"W4396591215","doi":"10.1158/1538-7445.sabcs23-gs02-01","title":"Abstract GS02-01: Randomized phase 3 study of datopotamab deruxtecan vs chemotherapy for patients with previously-treated inoperable or metastatic hormone receptor-positive, HER2-negative breast cancer: Results from TROPION-Breast01","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Metastatic breast cancer; Oncology; Hormone receptor; Chemotherapy; Internal medicine; Breast cancer; Cancer; HER2 negative","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00204809,0.001942289,0.002256704,0.0004574308,0.0004159969,0.001452555,0.001153914,0.001593856,0.01115157],"category_scores_gemma":[0.001487401,0.0006355788,0.002253512,0.0005760238,0.001233726,0.001095509,0.0004878834,0.004290819,0.001612844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00145599,"about_ca_system_score_gemma":0.001851283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409741,"about_ca_topic_score_gemma":0.003943502,"domain_scores_codex":[0.9994009,0.0003445479,0.00002575756,0.00009498472,0.00004119282,0.00009267571],"domain_scores_gemma":[0.9990168,0.0002139801,0.0002095472,0.00007226985,0.00005316819,0.0004342685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9733554,0.01033892,0.0007120508,0.0002859884,0.000647716,0.00003630543,0.00005032988,0.0004454926,0.00233571,0.0000880365,0.001422397,0.01028164],"study_design_scores_gemma":[0.9000209,0.09666676,0.001645701,0.0000176485,0.0002655096,0.00003250086,0.00002166053,0.0003216077,0.0002220091,0.0001600653,0.0006131258,0.00001255164],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828152,0.002490785,0.0005531343,0.001280767,0.0005787738,0.005860782,0.002890602,0.00020704,0.003322873],"genre_scores_gemma":[0.9780267,0.001655414,0.001374921,0.003045605,0.0004833779,0.006097179,0.003661439,0.00006062914,0.005594676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01115157,"threshold_uncertainty_score":0.03730577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03609913088047207,"score_gpt":0.3900478600258503,"score_spread":0.3539487291453782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}