{"id":"W4396591215","doi":"10.1158/1538-7445.sabcs23-gs02-01","title":"Abstract GS02-01: Randomized phase 3 study of datopotamab deruxtecan vs chemotherapy for patients with previously-treated inoperable or metastatic hormone receptor-positive, HER2-negative breast cancer: Results from TROPION-Breast01","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Metastatic breast cancer; Oncology; Hormone receptor; Chemotherapy; Internal medicine; Breast cancer; Cancer; HER2 negative","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001159365,0.0005881641,0.001787256,0.0004752175,0.0002737101,0.0001215308,0.000383717,0.0001193404,0.001067943],"category_scores_gemma":[0.0003350566,0.0003778572,0.0002027383,0.00145494,0.0006893601,0.0004396263,0.00007881701,0.0007616665,0.00001173262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001279311,"about_ca_system_score_gemma":0.00159526,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02346957,"about_ca_topic_score_gemma":0.001228786,"domain_scores_codex":[0.9946902,0.000569016,0.001042011,0.00129218,0.001417865,0.0009887641],"domain_scores_gemma":[0.9943416,0.002304576,0.000320405,0.0008050348,0.001830646,0.0003976979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8725265,0.004119953,0.0009769979,0.0004938808,0.004689634,0.00005831167,0.008556309,0.00007519093,0.00631675,0.000008752489,0.0007818076,0.1013959],"study_design_scores_gemma":[0.9185987,0.01066298,0.02707099,0.005089313,0.001261986,0.00001873433,0.004468967,0.0004063649,0.02948669,0.0002426561,0.001818345,0.0008743125],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757166,0.003139232,0.0002247764,0.001602049,0.0001585043,0.01150301,0.007456364,0.0001411705,0.0000582739],"genre_scores_gemma":[0.9892939,0.002210164,0.001117352,0.00009293526,0.0003269887,0.005304718,0.0005937221,0.0002125197,0.0008477317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1005216,"threshold_uncertainty_score":0.9998673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03609913088047207,"score_gpt":0.3900478600258503,"score_spread":0.3539487291453782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}