{"id":"W4396591228","doi":"10.1158/1538-7445.sabcs23-po1-04-07","title":"Abstract PO1-04-07: Disitamab vedotin, a clinical stage HER2-directed antibody-drug conjugate, shows potent antitumor activity as a monotherapy and in combination with tucatinib in preclinical breast cancer models","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Seagen (Canada)","funders":"","keywords":"Medicine; Antibody-drug conjugate; Cancer; Oncology; Stage (stratigraphy); Breast cancer; Drug; Internal medicine; Conjugate; Pharmacology; Antibody; Monoclonal antibody; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001108437,0.0003279227,0.0002684616,0.0001957368,0.0001024216,0.0002659758,0.0002106427,0.0002497642,0.002381851],"category_scores_gemma":[0.00007627285,0.00008891077,0.0001391626,0.0001496776,0.0001157894,0.0001827278,0.00009054395,0.0006472681,0.0004526993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003409615,"about_ca_system_score_gemma":0.0002811642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009109679,"about_ca_topic_score_gemma":0.0009365376,"domain_scores_codex":[0.999923,0.0000133297,0.000004580371,0.00001275802,0.00001933085,0.00002709571],"domain_scores_gemma":[0.9999614,0.000005876139,0.000007191808,0.000003535227,0.000005279956,0.00001677135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002530152,0.001378277,0.0004626107,0.00009945316,0.00002422437,0.00009811673,0.00001993688,0.0007041163,0.9749341,0.0001940425,0.00132651,0.01822851],"study_design_scores_gemma":[0.0004446023,0.009241559,0.003752928,0.000006244452,0.00003596287,0.0004212888,0.00001397268,0.00192143,0.9776898,0.00003763381,0.006428671,0.000005856998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921607,0.001390546,0.00120589,0.0001653488,0.00003885787,0.0000865826,0.0008150405,0.0001311692,0.004005724],"genre_scores_gemma":[0.992446,0.0006378717,0.0008972018,0.00005245456,0.00001017406,0.00005479061,0.00170773,0.00001949134,0.004174278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002381851,"threshold_uncertainty_score":0.007968128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1508340742934629,"score_gpt":0.5248850737820561,"score_spread":0.3740509994885932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}