{"id":"W4396591725","doi":"10.1158/1538-7445.sabcs23-ps06-04","title":"Abstract PS06-04: The prognostic and predictive impact of circulating tumour DNA (ctDNA) dynamics in patients with metastatic Triple Negative Breast Cancer (TNBC) on olaparib based therapy: Results from Cohort E of the PlasmaMATCH trial","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Olaparib; Medicine; Triple-negative breast cancer; Oncology; Breast cancer; Internal medicine; Cancer; Metastatic breast cancer; Cohort; DNA; Biology; Poly ADP ribose polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001809547,0.0005834072,0.000610604,0.0002020732,0.0002816291,0.001036445,0.0004727465,0.0005954751,0.002260716],"category_scores_gemma":[0.001983535,0.0002177594,0.0007646562,0.0002868834,0.0003381269,0.0006604418,0.0005327843,0.001242848,0.0005874304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003964937,"about_ca_system_score_gemma":0.0006029317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006430136,"about_ca_topic_score_gemma":0.0009250988,"domain_scores_codex":[0.9994937,0.0002462773,0.00003014799,0.0001220715,0.00006169599,0.00004610902],"domain_scores_gemma":[0.9983038,0.0003961175,0.0003664432,0.000204476,0.0001776535,0.0005515477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4359495,0.004524708,0.4899161,0.0002224993,0.002309809,0.0001768058,0.0002628348,0.001620549,0.008300066,0.0001508236,0.007250169,0.0493162],"study_design_scores_gemma":[0.05857922,0.1237808,0.7985976,0.00007999915,0.001869151,0.0006663002,0.0002914621,0.003423681,0.004708817,0.0005886357,0.007347177,0.00006721223],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960449,0.0003593654,0.0001590005,0.0001673134,0.00002588647,0.0001269496,0.002392319,0.00001523817,0.0007090328],"genre_scores_gemma":[0.9920974,0.0001856616,0.00029665,0.0002542274,0.00008263078,0.0001609292,0.005998149,0.00001062669,0.0009137911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002260716,"threshold_uncertainty_score":0.009569943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02395909323853186,"score_gpt":0.3259963800096593,"score_spread":0.3020372867711275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}