{"id":"W4396596413","doi":"10.1158/1538-7445.sabcs23-rf02-01","title":"Abstract RF02-01: A Multicenter, Phase I/II Trial of Anastrozole, Palbociclib, Trastuzumab, and Pertuzumab in Hormone Receptor (HR)-Positive, HER2-Positive Metastatic Breast Cancer (ASPIRE)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Pertuzumab; Palbociclib; Anastrozole; Medicine; Trastuzumab; Metastatic breast cancer; Oncology; Internal medicine; Breast cancer; Letrozole; Hormone receptor; Cancer; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009663808,0.0004559481,0.00094663,0.0008352385,0.0002052584,0.00008873552,0.0002592869,0.0001491762,0.001034753],"category_scores_gemma":[0.0001032375,0.0003959885,0.0002000249,0.001374631,0.0008696555,0.0004951184,0.0001755229,0.001277415,0.00001734158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001694578,"about_ca_system_score_gemma":0.001288318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005341879,"about_ca_topic_score_gemma":0.0005543648,"domain_scores_codex":[0.9956341,0.000295739,0.0008054959,0.000990515,0.001204,0.001070124],"domain_scores_gemma":[0.9979426,0.0005184499,0.0001419455,0.0004355738,0.0005147762,0.0004466572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.189321,0.003509531,0.0003319371,0.001175345,0.001117823,0.0004579467,0.006638361,0.00004001462,0.2856127,0.00009513725,0.001299692,0.5104005],"study_design_scores_gemma":[0.6011938,0.04438296,0.1229029,0.02521067,0.001364985,0.0005533315,0.01270344,0.003727362,0.1586175,0.0006201962,0.02571788,0.003005009],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646608,0.02452308,0.00008176537,0.005360013,0.0003643788,0.002580146,0.002123799,0.00007828513,0.0002277117],"genre_scores_gemma":[0.9912845,0.005663423,0.0003805428,0.0001381462,0.0005683316,0.001164983,0.00008289881,0.0001298607,0.0005872482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5073956,"threshold_uncertainty_score":0.9998784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05262329245330408,"score_gpt":0.4284209011597165,"score_spread":0.3757976087064124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}