{"id":"W4396596413","doi":"10.1158/1538-7445.sabcs23-rf02-01","title":"Abstract RF02-01: A Multicenter, Phase I/II Trial of Anastrozole, Palbociclib, Trastuzumab, and Pertuzumab in Hormone Receptor (HR)-Positive, HER2-Positive Metastatic Breast Cancer (ASPIRE)","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Pertuzumab; Palbociclib; Anastrozole; Medicine; Trastuzumab; Metastatic breast cancer; Oncology; Internal medicine; Breast cancer; Letrozole; Hormone receptor; Cancer; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002196584,0.002437705,0.001633076,0.0005348557,0.0004485,0.001075619,0.001482509,0.001355905,0.004874199],"category_scores_gemma":[0.0009993098,0.000740843,0.001034299,0.0004694705,0.001105735,0.0009225568,0.0004637701,0.003896871,0.001324478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009618821,"about_ca_system_score_gemma":0.001916721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001328872,"about_ca_topic_score_gemma":0.00288666,"domain_scores_codex":[0.9994493,0.0002763418,0.00002456671,0.00009134502,0.00004060882,0.0001178526],"domain_scores_gemma":[0.9991835,0.0001160873,0.0001155454,0.00005805274,0.00005636826,0.0004705267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8096106,0.07161677,0.005445199,0.0005781891,0.001105897,0.0003178691,0.0002097692,0.002004204,0.04794643,0.000251556,0.006068226,0.05484521],"study_design_scores_gemma":[0.7314676,0.2587121,0.005170908,0.00001788536,0.0002879078,0.0002097734,0.00003059268,0.0005568738,0.002136573,0.00006429459,0.00132954,0.00001593739],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907386,0.001319369,0.0004477948,0.0006191366,0.0001353032,0.002854286,0.001487003,0.0002096673,0.002188737],"genre_scores_gemma":[0.982811,0.00116455,0.00183004,0.00114118,0.0002977411,0.003682415,0.004590362,0.00005106999,0.004431754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004874199,"threshold_uncertainty_score":0.0163058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05262329245330408,"score_gpt":0.4284209011597165,"score_spread":0.3757976087064124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}