{"id":"W4396597566","doi":"10.1158/1538-7445.sabcs23-po1-01-08","title":"Abstract PO1-01-08: The impact of drug-drug interactions between palbociclib and proton pump inhibitors on clinical outcomes of patients with hormone receptor positive, HER2-negative, early breast cancer: an exploratory analysis of the PALLAS study","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Palbociclib; Drug; Oncology; Cancer; Breast cancer; Hormone receptor; Internal medicine; Pharmacology; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001213559,0.0002806009,0.0008992599,0.0004733694,0.000162748,0.00003902608,0.0003331925,0.000058165,0.0001750946],"category_scores_gemma":[0.0001071407,0.0001404341,0.0003242899,0.001965193,0.001075557,0.0003215533,0.0001503549,0.001030169,0.000001804398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004767145,"about_ca_system_score_gemma":0.0006911526,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01296058,"about_ca_topic_score_gemma":0.002524053,"domain_scores_codex":[0.9963456,0.0007256971,0.0007678666,0.0005451518,0.001241733,0.0003739075],"domain_scores_gemma":[0.9964238,0.001263963,0.0003657365,0.0007067259,0.001036824,0.000202979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004000071,0.0009193879,0.9685522,0.0001004803,0.005966703,0.00000223201,0.008627767,0.0001037804,0.000770166,0.000002679622,0.0001026748,0.01085183],"study_design_scores_gemma":[0.002117163,0.00142879,0.9881837,0.0005799236,0.0006407729,2.821069e-7,0.004201,0.00001162742,0.002652975,0.00001630154,0.00003677069,0.0001306673],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939001,0.0003762198,0.000001564694,0.0008382056,0.00009589719,0.002933341,0.001800124,0.00002221646,0.00003230261],"genre_scores_gemma":[0.9988729,0.0002242273,0.00001030812,0.00001714836,0.000147386,0.0005555991,0.00002402499,0.00005604625,0.00009231361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0196315,"threshold_uncertainty_score":0.9936122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06028534070307063,"score_gpt":0.447671778744674,"score_spread":0.3873864380416034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}