{"id":"W4396597566","doi":"10.1158/1538-7445.sabcs23-po1-01-08","title":"Abstract PO1-01-08: The impact of drug-drug interactions between palbociclib and proton pump inhibitors on clinical outcomes of patients with hormone receptor positive, HER2-negative, early breast cancer: an exploratory analysis of the PALLAS study","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Palbociclib; Drug; Oncology; Cancer; Breast cancer; Hormone receptor; Internal medicine; Pharmacology; Metastatic breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007143178,0.001039537,0.001561736,0.0004015402,0.0003270382,0.001514733,0.001205285,0.0006952311,0.00364686],"category_scores_gemma":[0.005244015,0.0004010196,0.004490769,0.0007376865,0.0007850059,0.001134799,0.00103001,0.002495101,0.0004296409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009041064,"about_ca_system_score_gemma":0.001623822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007166502,"about_ca_topic_score_gemma":0.001366383,"domain_scores_codex":[0.9959895,0.002591477,0.0001904135,0.0005329227,0.0004809634,0.0002146236],"domain_scores_gemma":[0.9945953,0.00207484,0.001684432,0.0004778475,0.0002644227,0.0009031178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7905829,0.004387049,0.1374024,0.001438286,0.0212254,0.0002823198,0.0001133953,0.002336403,0.004435825,0.0002826543,0.003590261,0.03392308],"study_design_scores_gemma":[0.2175437,0.1966062,0.5439189,0.0002004901,0.02287059,0.0006739712,0.0002359487,0.004363759,0.003245765,0.0009982935,0.009213777,0.0001285203],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865001,0.003381232,0.0005625495,0.000506422,0.00007389297,0.0007951852,0.006214655,0.00004550161,0.001920476],"genre_scores_gemma":[0.9916487,0.0004655817,0.0005710828,0.000317586,0.0001245762,0.000565662,0.005425439,0.00001426139,0.0008671297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007143178,"threshold_uncertainty_score":0.03777725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06028534070307063,"score_gpt":0.447671778744674,"score_spread":0.3873864380416034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}