{"id":"W4396598458","doi":"10.1016/j.celrep.2024.114173","title":"Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Canada Research Chairs; Hospital for Sick Children","funders":"Epilepsy Canada; Canadian Institutes of Health Research; University of Toronto; Scottish Rite Charitable Foundation of Canada; San Francisco Foundation; Canada First Research Excellence Fund; Canada Research Chairs; Brain and Behavior Research Foundation; Simons Foundation Autism Research Initiative; Fondation Brain Canada; Stem Cell Network; Simons Foundation","keywords":"mTORC1; PTEN; mTORC2; Organoid; Neuroscience; Hyperactivation; Biology; Cell biology; PI3K/AKT/mTOR pathway; Cancer research; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001518427,0.00049797,0.0003046116,0.0004607493,0.0002098911,0.0003173453,0.0002136165,0.0002069739,0.000948427],"category_scores_gemma":[0.0001035179,0.0002209958,0.0002572558,0.0002238817,0.0004318297,0.0001526353,0.0005200372,0.000456038,0.0002324682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798644,"about_ca_system_score_gemma":0.0003356262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005886354,"about_ca_topic_score_gemma":0.001273968,"domain_scores_codex":[0.999796,0.0000247396,0.00002168728,0.00004188329,0.00008302656,0.00003267104],"domain_scores_gemma":[0.9999217,0.000009961157,0.00002315879,0.000009915133,0.000005550292,0.00002971561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006230459,0.00001107791,0.0003310346,0.00002490599,0.00001234667,0.0002287111,0.000009466764,0.0001586957,0.9981068,0.000228802,0.00004414733,0.0007815185],"study_design_scores_gemma":[0.00001402179,0.00009598874,0.00623435,0.000005359988,0.00003851639,0.001404259,0.00003058371,0.001115526,0.9890382,0.0001467144,0.001869887,0.000006525211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926872,0.001116226,0.003442494,0.00009787873,0.00002406352,0.00002481855,0.0004639484,0.0001335496,0.002009861],"genre_scores_gemma":[0.9965016,0.0005939385,0.001370335,0.00003056723,0.000005332908,0.00003060477,0.0002987132,0.00001863823,0.001150237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000948427,"threshold_uncertainty_score":0.003172815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178983241140503,"score_gpt":0.2516703280186786,"score_spread":0.2398804956072736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}