{"id":"W4396598458","doi":"10.1016/j.celrep.2024.114173","title":"Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Canada Research Chairs; Hospital for Sick Children","funders":"Epilepsy Canada; Canadian Institutes of Health Research; University of Toronto; Scottish Rite Charitable Foundation of Canada; San Francisco Foundation; Canada First Research Excellence Fund; Canada Research Chairs; Brain and Behavior Research Foundation; Simons Foundation Autism Research Initiative; Fondation Brain Canada; Stem Cell Network; Simons Foundation","keywords":"mTORC1; PTEN; mTORC2; Organoid; Neuroscience; Hyperactivation; Biology; Cell biology; PI3K/AKT/mTOR pathway; Cancer research; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718655,0.0001040597,0.0001243186,0.00002962066,0.00006924698,0.00002786827,0.00004684677,0.00006509358,0.00001289784],"category_scores_gemma":[0.00007411894,0.00007853187,0.00003769342,0.00005476327,0.0002855964,0.000005503682,0.00007513609,0.00008867373,1.31147e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009403343,"about_ca_system_score_gemma":0.00006933074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005366125,"about_ca_topic_score_gemma":0.000008135753,"domain_scores_codex":[0.9991724,0.00004363114,0.0002873866,0.0002431558,0.0001348539,0.0001186034],"domain_scores_gemma":[0.9994932,0.00006222673,0.0001135726,0.0002398507,0.00005485424,0.00003627203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001047803,0.00002245435,0.004906004,0.0001455603,0.00002141216,0.0000291569,0.0001601853,0.000133696,0.9937029,0.0003880328,0.0002814754,0.0001986672],"study_design_scores_gemma":[0.0001322051,0.0003736299,0.01736998,0.00006315814,0.0001128726,0.0002168996,0.0003073812,0.0003817406,0.974602,0.0002417248,0.006007816,0.000190548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952532,0.003137635,0.0003097414,0.00004417137,0.0002424865,0.00009127593,0.000006312812,0.00001076941,0.0009044241],"genre_scores_gemma":[0.9992992,0.00008043241,0.00002684102,0.00003280756,0.00008198238,0.000006309676,0.00001677585,0.00001780446,0.0004378908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01910084,"threshold_uncertainty_score":0.3202437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178983241140503,"score_gpt":0.2516703280186786,"score_spread":0.2398804956072736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}