{"id":"W4396599098","doi":"10.1158/1538-7445.sabcs23-po1-18-12","title":"Abstract PO1-18-12: Trial in progress: Open-label, randomized, multicenter, phase 3, ELAINE 3 study of the efficacy and safety of lasofoxifene plus abemaciclib for treating locally advanced or ER+/HER2- metastatic breast cancer with an ESR1 mutation","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Open label; Randomized controlled trial; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002737805,0.002673585,0.003596839,0.0004942154,0.0006382987,0.001962877,0.001390286,0.00250626,0.007884923],"category_scores_gemma":[0.001518743,0.000874891,0.001950601,0.0005359238,0.001859945,0.001597079,0.0004698352,0.005990495,0.002321637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008906022,"about_ca_system_score_gemma":0.001822091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171933,"about_ca_topic_score_gemma":0.002899438,"domain_scores_codex":[0.9992548,0.0003796102,0.00002872465,0.0001292628,0.00007480089,0.0001327836],"domain_scores_gemma":[0.9989572,0.000192862,0.0002353179,0.00009019188,0.00007713144,0.0004473024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9454515,0.01669543,0.0009080735,0.0006536935,0.0008389906,0.0001018371,0.0001061318,0.0005163409,0.008368378,0.0002943383,0.003750994,0.02231427],"study_design_scores_gemma":[0.9436235,0.05345758,0.0009611831,0.00001774909,0.0001467865,0.00005435039,0.00001781312,0.0003184789,0.0004163725,0.0001298742,0.0008431704,0.00001312652],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697661,0.005413833,0.00178679,0.002270376,0.0006969847,0.009434557,0.005261842,0.0005281647,0.004841299],"genre_scores_gemma":[0.9413741,0.005276403,0.005761713,0.004604673,0.001021495,0.01582722,0.009816511,0.0002012263,0.01611666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007884923,"threshold_uncertainty_score":0.02637768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1098265694993603,"score_gpt":0.4989883495578806,"score_spread":0.3891617800585203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}