{"id":"W4396599098","doi":"10.1158/1538-7445.sabcs23-po1-18-12","title":"Abstract PO1-18-12: Trial in progress: Open-label, randomized, multicenter, phase 3, ELAINE 3 study of the efficacy and safety of lasofoxifene plus abemaciclib for treating locally advanced or ER+/HER2- metastatic breast cancer with an ESR1 mutation","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Open label; Randomized controlled trial; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002258076,0.0003127473,0.001224626,0.0002970549,0.000156355,0.0000814646,0.0003757362,0.00006298131,0.0001571163],"category_scores_gemma":[0.0004083085,0.0001789946,0.00006301657,0.0009298412,0.0007184418,0.0004592414,0.0001366589,0.0004797773,3.582969e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005528841,"about_ca_system_score_gemma":0.001539061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001877733,"about_ca_topic_score_gemma":0.004096867,"domain_scores_codex":[0.9963797,0.0005449356,0.0009475538,0.0006965639,0.0008846674,0.0005466205],"domain_scores_gemma":[0.9966971,0.001675844,0.0003181913,0.0004830385,0.0006562488,0.0001696145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7265538,0.003081444,0.000126989,0.001166067,0.0006248117,0.00005331338,0.003468491,0.0007520217,0.004269338,0.00001851959,0.000005418699,0.2598798],"study_design_scores_gemma":[0.9703427,0.008873126,0.001417591,0.004811034,0.000438364,0.00003521979,0.004519628,0.00587136,0.003337929,0.0000448469,0.00008905904,0.0002191502],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975099,0.004469844,0.0002610727,0.0007609622,0.0001440408,0.01885813,0.0003520868,0.00003372912,0.00002114776],"genre_scores_gemma":[0.9911486,0.0004574825,0.001928254,0.000026676,0.0001488192,0.005968957,0.0000268841,0.00009489966,0.0001994579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2596607,"threshold_uncertainty_score":0.7299188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1098265694993603,"score_gpt":0.4989883495578806,"score_spread":0.3891617800585203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}