{"id":"W4396599443","doi":"10.1158/1538-7445.sabcs23-ps09-08","title":"Abstract PS09-08: Genomic characterization of endocrine resistance in ER+HER2+ breast cancers in the POETIC Trial","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Medicine; Endocrine system; Breast cancer; Oncology; Internal medicine; Cancer research; Cancer; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001124623,0.0001733809,0.0003600412,0.0005371485,0.00005234548,0.00004702319,0.0003207914,0.00007265606,0.000556878],"category_scores_gemma":[0.00006670896,0.0001327747,0.00007557785,0.001461732,0.0002938447,0.0001838684,0.00004963941,0.0008500555,0.00002567695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001666766,"about_ca_system_score_gemma":0.001349617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001946897,"about_ca_topic_score_gemma":0.003288917,"domain_scores_codex":[0.9975061,0.0001898164,0.0004893119,0.0004529062,0.0007690348,0.0005928498],"domain_scores_gemma":[0.9989921,0.0002465687,0.00006670869,0.0004546741,0.0001610125,0.00007893179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.06007627,0.0003052961,0.003336424,0.002159686,0.0001432235,0.000645593,0.007893395,0.0001209295,0.8298854,0.001521138,0.0003708209,0.09354182],"study_design_scores_gemma":[0.04272345,0.0005964116,0.850142,0.006042553,0.00005714995,0.0001308289,0.001912984,0.0001586326,0.01863553,0.00206002,0.07698887,0.0005515399],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843503,0.006995711,0.00001807432,0.005593779,0.0003337107,0.001464815,0.0001329565,0.00003072441,0.001079993],"genre_scores_gemma":[0.995834,0.001677621,0.00003603602,0.0001142614,0.0006309074,0.0007073429,0.00003589447,0.00004964551,0.0009143205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8468056,"threshold_uncertainty_score":0.6097423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05891477362471634,"score_gpt":0.4099722021907961,"score_spread":0.3510574285660797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}