{"id":"W4396599802","doi":"10.1158/1538-7445.sabcs23-ps12-09","title":"Abstract PS12-09: Capivasertib plus cyclin-dependent kinase 4/6 inhibitor and fulvestrant in hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: updated Phase 1b analysis from CAPItello-292","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean","funders":"","keywords":"Fulvestrant; Human Epidermal Growth Factor Receptor 2; Oncology; Internal medicine; Hormone receptor; Cancer research; Medicine; Cancer; Breast cancer; Epidermal growth factor receptor; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007464331,0.0008098437,0.001482597,0.001610387,0.0003979123,0.0002500972,0.0004343448,0.0003768489,0.004466275],"category_scores_gemma":[0.0001309884,0.0007388035,0.0003327942,0.002900244,0.0009340034,0.0009473324,0.000229139,0.002343092,0.00009997591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003799057,"about_ca_system_score_gemma":0.00135541,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03108691,"about_ca_topic_score_gemma":0.004753761,"domain_scores_codex":[0.9931187,0.0004544417,0.001143725,0.002039174,0.001643387,0.001600561],"domain_scores_gemma":[0.9964842,0.0006554247,0.0002205798,0.0007618962,0.0008640139,0.001013914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01053117,0.001145605,0.003635734,0.000383302,0.00316619,0.0009735893,0.006452695,0.0002331307,0.8846772,0.00006021711,0.0007724575,0.08796871],"study_design_scores_gemma":[0.05204157,0.001672113,0.2622772,0.003552414,0.001482969,0.0000768678,0.005739734,0.00129963,0.6655076,0.001030794,0.002721842,0.00259738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9598715,0.02430543,0.00009739382,0.004388603,0.0004171168,0.001772219,0.008806712,0.0002395424,0.0001014776],"genre_scores_gemma":[0.9890935,0.00675444,0.0003680808,0.0001577989,0.001076884,0.0008756401,0.0009226927,0.0001973509,0.0005536417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2586414,"threshold_uncertainty_score":0.9999585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03672440036031972,"score_gpt":0.3882298435116482,"score_spread":0.3515054431513285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}