{"id":"W4396599802","doi":"10.1158/1538-7445.sabcs23-ps12-09","title":"Abstract PS12-09: Capivasertib plus cyclin-dependent kinase 4/6 inhibitor and fulvestrant in hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: updated Phase 1b analysis from CAPItello-292","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean","funders":"","keywords":"Fulvestrant; Human Epidermal Growth Factor Receptor 2; Oncology; Internal medicine; Hormone receptor; Cancer research; Medicine; Cancer; Breast cancer; Epidermal growth factor receptor; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003061557,0.00104964,0.002725462,0.0008805781,0.0003317764,0.001671213,0.001417216,0.001066616,0.006230748],"category_scores_gemma":[0.001456057,0.0005667012,0.002091536,0.001122135,0.0005088545,0.0009978961,0.000407941,0.002987193,0.001156911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001787394,"about_ca_system_score_gemma":0.002261046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002822504,"about_ca_topic_score_gemma":0.009456202,"domain_scores_codex":[0.9991024,0.0003611973,0.00007828921,0.0001367174,0.0002036855,0.0001178913],"domain_scores_gemma":[0.9988882,0.0002048241,0.0003113244,0.00008177682,0.0001763806,0.0003376337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.307598,0.01211061,0.01207055,0.007690592,0.009340256,0.0005351311,0.0002830601,0.007867115,0.06957377,0.001118371,0.0690896,0.5027229],"study_design_scores_gemma":[0.4696798,0.2623465,0.07921796,0.001348071,0.01224447,0.002694702,0.0001691473,0.005853732,0.02026754,0.001308878,0.1445987,0.0002704114],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7596979,0.1394187,0.004179633,0.006061159,0.001592044,0.006995958,0.05332898,0.001146566,0.02757907],"genre_scores_gemma":[0.8328936,0.0585967,0.006052337,0.008131248,0.001019859,0.003839031,0.07689539,0.0004104778,0.01216132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006230748,"threshold_uncertainty_score":0.02084392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03672440036031972,"score_gpt":0.3882298435116482,"score_spread":0.3515054431513285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}