{"id":"W4396601380","doi":"10.1093/braincomms/fcae159","title":"Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Brain Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Fonds de Recherche du Québec - Santé; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; University of California, San Francisco; National Institutes of Health; Genentech; Fleni; Eisai; Korea Health Industry Development Institute; Fondation Brain Canada; GHR Foundation; Deutsches Zentrum für Neurodegenerative Erkrankungen; Instituto de Salud Carlos III; Amgen; Horizon Pharmaceuticals; Japan Agency for Medical Research and Development; Avid Radiopharmaceuticals; Canadian Institutes of Health Research; Foundation for Barnes-Jewish Hospital; F. Hoffmann-La Roche; Pfizer; Biogen; AstraZeneca; Eli Lilly and Company; Bayer Vital; Michael J. Fox Foundation for Parkinson's Research; Sanofi; Alzheimer's Association","keywords":"Neuroimaging; Early-onset Alzheimer's disease; Disease; Alzheimer's disease; Medicine; Neuroscience; Psychology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008320387,0.0004040346,0.000376691,0.001342621,0.0003033396,0.0003148495,0.0002424251,0.0003100765,0.0009089533],"category_scores_gemma":[0.001862237,0.0001988854,0.0001482016,0.0003975931,0.0003285821,0.0002824514,0.0002851292,0.0001495686,0.0001049255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002921581,"about_ca_system_score_gemma":0.0001962717,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003238962,"about_ca_topic_score_gemma":0.004994155,"domain_scores_codex":[0.9997172,0.00009204925,0.0000323418,0.00006314842,0.00004641234,0.00004894273],"domain_scores_gemma":[0.9994837,0.0001717889,0.0001584375,0.00003051411,0.00007066302,0.00008486163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009155314,0.0001015216,0.9804673,0.00004802528,0.00007225995,0.002614249,0.0004955149,0.00006777967,0.0107465,0.00005426129,0.0000969218,0.004320299],"study_design_scores_gemma":[0.00001488721,0.0002018843,0.9946714,0.000008084272,0.0000279061,0.003874274,0.0002534289,0.0001257591,0.0006599679,0.00004568369,0.0001141301,0.000002547842],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996505,0.0001818181,0.00002457937,0.000005919967,9.134276e-7,0.000001704551,0.00001715398,7.55253e-7,0.0001166548],"genre_scores_gemma":[0.9997261,0.0000719302,0.0000845442,0.000009503288,0.000003731058,0.000002226642,0.00005464026,7.857684e-7,0.00004643113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003238962,"threshold_uncertainty_score":0.006440222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07691132519614945,"score_gpt":0.384033794074023,"score_spread":0.3071224688778735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}