{"id":"W4396601380","doi":"10.1093/braincomms/fcae159","title":"Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Brain Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Fonds de Recherche du Québec - Santé; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; University of California, San Francisco; National Institutes of Health; Genentech; Fleni; Eisai; Korea Health Industry Development Institute; Fondation Brain Canada; GHR Foundation; Deutsches Zentrum für Neurodegenerative Erkrankungen; Instituto de Salud Carlos III; Amgen; Horizon Pharmaceuticals; Japan Agency for Medical Research and Development; Avid Radiopharmaceuticals; Canadian Institutes of Health Research; Foundation for Barnes-Jewish Hospital; F. Hoffmann-La Roche; Pfizer; Biogen; AstraZeneca; Eli Lilly and Company; Bayer Vital; Michael J. Fox Foundation for Parkinson's Research; Sanofi; Alzheimer's Association","keywords":"Neuroimaging; Early-onset Alzheimer's disease; Disease; Alzheimer's disease; Medicine; Neuroscience; Psychology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001970855,0.0001795616,0.000191477,0.0003309512,0.000146422,0.00009163685,0.0004122665,0.00003686424,0.00006149041],"category_scores_gemma":[0.0002567533,0.0001758198,0.0001409329,0.0007388151,0.0002615563,0.0001622285,0.0002760656,0.0003941541,0.0002623579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009108026,"about_ca_system_score_gemma":0.000553054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002051056,"about_ca_topic_score_gemma":0.00003193751,"domain_scores_codex":[0.9985307,0.000239271,0.0002555211,0.0003266342,0.0002980688,0.0003498412],"domain_scores_gemma":[0.9970225,0.0004985596,0.00002908712,0.001829474,0.00005952055,0.000560844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01333158,0.01172924,0.7095279,0.0009702106,0.0291233,0.04545494,0.00405646,0.0001481078,0.001346206,0.03652941,0.0399077,0.1078749],"study_design_scores_gemma":[0.005688774,0.0002417284,0.944782,0.00098563,0.001905418,0.00004474577,0.0001668234,0.02070044,0.00008483506,0.00193858,0.02296582,0.0004951895],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7840146,0.1566812,0.00003015629,0.05458647,0.0001303989,0.001157551,0.0001690922,0.0002891628,0.002941436],"genre_scores_gemma":[0.997287,0.0009923737,0.0004393084,0.0004558832,0.00002373709,0.0002060449,0.0005025013,0.00005142423,0.00004174124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2352541,"threshold_uncertainty_score":0.7169725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07691132519614945,"score_gpt":0.384033794074023,"score_spread":0.3071224688778735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}