{"id":"W4396609669","doi":"10.1016/j.biopsych.2024.04.016","title":"Circulating Metabolite Abundances Associated With Risks of Bipolar Disorder, Schizophrenia, and Depression: A Mendelian Randomization Study","year":2024,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill Genome Centre; McGill University; Montreal General Hospital; Jewish General Hospital; University of Toronto","funders":"Lady Davis Institute for Medical Research; Fonds de Recherche du Québec - Santé; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; McGill University","keywords":"Mendelian randomization; Schizophrenia (object-oriented programming); Bipolar disorder; Depression (economics); Metabolite; Psychiatry; Polygenic risk score; Psychology; Clinical psychology; Medicine; Genetics; Internal medicine; Biology; Cognition; Gene; Genotype; Genetic variants; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01444246,0.001027485,0.0009410613,0.0009713818,0.0007137025,0.0008405898,0.0008951592,0.001135675,0.001935725],"category_scores_gemma":[0.02666388,0.000557686,0.001852169,0.00130375,0.0009402014,0.000435884,0.0006432238,0.0006708346,0.0001806553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005240841,"about_ca_system_score_gemma":0.0007405483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004564031,"about_ca_topic_score_gemma":0.002090688,"domain_scores_codex":[0.9821592,0.0124045,0.0007040168,0.003341607,0.0009615892,0.0004290492],"domain_scores_gemma":[0.984556,0.007526359,0.003200124,0.003818857,0.0004830536,0.0004155871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01956354,0.0004079404,0.933279,0.0001871956,0.01131658,0.00193753,0.0005677415,0.002693061,0.008274404,0.003469459,0.001363458,0.0169401],"study_design_scores_gemma":[0.004706132,0.007037413,0.9041395,0.0001157349,0.01105569,0.006662307,0.0003617356,0.05180074,0.002975601,0.007459801,0.003457912,0.0002273999],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739951,0.0007216621,0.02339854,0.0002191294,0.00005573842,0.0002619669,0.0006610649,0.0001242743,0.0005625287],"genre_scores_gemma":[0.9896588,0.0001088588,0.00942157,0.00009271482,0.0000223486,0.0001674549,0.0003050009,0.00002226132,0.0002010641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01444246,"threshold_uncertainty_score":0.07637995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03189878862236907,"score_gpt":0.3109468253074374,"score_spread":0.2790480366850683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}