{"id":"W4396616763","doi":"10.3390/cimb46050255","title":"Recent Therapeutic Gene Editing Applications to Genetic Disorders","year":2024,"lang":"en","type":"review","venue":"Current Issues in Molecular Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Health Canada; Government of Canada","keywords":"Genome editing; CRISPR; Cas9; Computational biology; Genetic enhancement; Transcription activator-like effector nuclease; Biology; Computer science; Bioinformatics; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001164764,0.001062641,0.00112792,0.001731441,0.0004826263,0.001629473,0.001016811,0.001447608,0.005548933],"category_scores_gemma":[0.00149551,0.0004212262,0.0007947497,0.001621603,0.001294678,0.001359825,0.001363357,0.003062689,0.002959525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008596035,"about_ca_system_score_gemma":0.0008129106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004255122,"about_ca_topic_score_gemma":0.0006170642,"domain_scores_codex":[0.999404,0.0001274774,0.00005985016,0.0001434526,0.0002074131,0.00005791248],"domain_scores_gemma":[0.999398,0.0003165357,0.00007257611,0.00003128287,0.0001249788,0.00005669157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001383573,0.0001102887,0.0002016336,0.01581308,0.0001325842,0.001238636,0.0004123725,0.00134722,0.04689137,0.03614462,0.05488896,0.8426809],"study_design_scores_gemma":[0.00001449894,0.00008802615,0.0001839319,0.0006771974,0.00007103261,0.001724015,0.00003630995,0.0002319859,0.007959549,0.004452862,0.9845309,0.00002978061],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001077709,0.9738816,0.009270297,0.001779014,0.001827669,0.00004141211,0.0000595608,0.000154304,0.01190837],"genre_scores_gemma":[0.00704145,0.9809455,0.004385864,0.0016665,0.001305528,0.00006138388,0.0001214605,0.00004079314,0.004431594],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005548933,"threshold_uncertainty_score":0.01856297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02543826433593848,"score_gpt":0.4410707447389453,"score_spread":0.4156324804030068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}