{"id":"W4396620188","doi":"10.1016/j.cell.2024.04.009","title":"FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"H2020 European Research Council; Penn State Hershey Cancer Institute; National Cancer Institute; National Institute of Dental and Craniofacial Research; European Research Council; National Center for Advancing Translational Sciences; Medical Research Council; National Institutes of Health; Fonds de dotation CSL Behring pour la recherche; Fondation Bettencourt Schueller; Société Française de Dermatologie et de Pathologie Sexuellement Transmissible; Howard Hughes Medical Institute; Vetenskapsrådet; Glenn Foundation for Medical Research; Honjo International Scholarship Foundation; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; KU Leuven; Fondation pour la Recherche Médicale; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Société Francophone du Diabète; Agence Nationale de la Recherche; CSL Behring; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Göran Gustafssons Stiftelse för Naturvetenskaplig och Medicinsk Forskning; Fonds Wetenschappelijk Onderzoek; Stavros Niarchos Foundation; Schlumberger Foundation; NHLBI Division of Intramural Research; University of Pennsylvania; LEO Fondet; Science for Life Laboratory; Rockefeller University; Institut National de la Santé et de la Recherche Médicale; Göran Gustafssons Stiftelser; St. Giles Foundation; Vlaamse regering; Pennsylvania State University; National Health and Medical Research Council; Fondation Schlumberger pour l’Education et la Recherche; Institut National Du Cancer; American Association of Immunologists","keywords":"Biology; Haematopoiesis; Bone marrow; Immunology; Progenitor cell; Myeloid; Dendritic cell; Cell biology; Immune system; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003645298,0.0005442789,0.0002923331,0.0009946944,0.0003640599,0.0004935986,0.0003051109,0.0007491105,0.001564827],"category_scores_gemma":[0.0003642975,0.0003188268,0.0002838649,0.0002563384,0.0008291297,0.00025181,0.0005265519,0.0004609852,0.0002663999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005032586,"about_ca_system_score_gemma":0.000305019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009807359,"about_ca_topic_score_gemma":0.001018608,"domain_scores_codex":[0.9995901,0.00008592254,0.0000468678,0.0001245783,0.00008059815,0.00007205993],"domain_scores_gemma":[0.9998358,0.00004054948,0.00006769176,0.00002281028,0.000007795916,0.00002526375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001788608,0.0001729043,0.02447728,0.0001620803,0.0001035603,0.009682261,0.0005344314,0.0008097288,0.9226332,0.005757137,0.001109468,0.03276932],"study_design_scores_gemma":[0.001066771,0.002409493,0.3161143,0.0003265376,0.0005608839,0.19445,0.0007943969,0.006716782,0.4178673,0.006648271,0.05284349,0.0002016977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909384,0.001912372,0.002850613,0.0002368931,0.00001366421,0.00004446839,0.0007192751,0.0001913017,0.003092971],"genre_scores_gemma":[0.9965586,0.0005367369,0.00164702,0.0001511629,0.00001287243,0.00003649529,0.0004506814,0.00004224356,0.0005641827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001564827,"threshold_uncertainty_score":0.005234897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01342498502442038,"score_gpt":0.2348505370366177,"score_spread":0.2214255520121973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}