{"id":"W4396626236","doi":"10.1038/s41422-024-00961-0","title":"A tale of two calcium channels: structural pharmacology of Cav2.1 and Cav3.2","year":2024,"lang":"en","type":"letter","venue":"Cell Research","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Calcium; Neuroscience; Calcium channel; Voltage-dependent calcium channel; Pharmacology; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002998546,0.0007385443,0.001046712,0.000454945,0.0026593,0.002408376,0.001469538,0.0340475,0.004586861],"category_scores_gemma":[0.01014842,0.0005827125,0.00103434,0.0002992626,0.003474436,0.003544241,0.001167224,0.03175316,0.00434223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003195666,"about_ca_system_score_gemma":0.001964064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00219657,"about_ca_topic_score_gemma":0.003525361,"domain_scores_codex":[0.9985508,0.0004057059,0.0001468756,0.0002222284,0.0004846523,0.0001896986],"domain_scores_gemma":[0.996108,0.002563125,0.0001438324,0.0001417614,0.0004750968,0.0005682413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000216702,0.00004792914,0.0003773813,0.00005952842,0.00002385354,0.00251242,0.00009919223,0.00008524467,0.0007660651,0.004829573,0.975071,0.01591112],"study_design_scores_gemma":[0.0004109083,0.0002178709,0.001547023,0.0001548614,0.00005183151,0.004528731,0.0004149312,0.0008349171,0.001385091,0.04747882,0.9428746,0.0001002873],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0007863489,0.003075199,0.0003360683,0.9611364,0.03257068,0.00001265533,0.00004754463,0.00003660273,0.001998557],"genre_scores_gemma":[0.009953931,0.002857107,0.0004923604,0.9110417,0.06346971,0.00005754301,0.00004927696,0.00003297822,0.01204532],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0340475,"threshold_uncertainty_score":0.02318633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06131915937449279,"score_gpt":0.3853090532153091,"score_spread":0.3239898938408163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}