{"id":"W4396626408","doi":"10.1016/j.xcrm.2024.101529","title":"Genetic variants for head size share genes and pathways with cancer","year":2024,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier Universitaire Sainte-Justine; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Center for Research Resources; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; National Institute on Aging; Japan Society for the Promotion of Science; Ministerie van Onderwijs, Cultuur en Wetenschap; National Health and Medical Research Council; Siemens Healthineers; Medical Research Council; Canadian Institutes of Health Research; Wake Forest School of Medicine; University of Alabama; Macquarie Group Foundation; Agence Nationale de la Recherche; Universität Greifswald; National Institutes of Health; Heinz Nixdorf Stiftung; Ramsay Health Care; University College London Hospitals NHS Foundation Trust; Sanofi; Fondation de France; National Heart, Lung, and Blood Institute; Kaiser Foundation Research Institute; University of Minnesota; Vetenskapsrådet; Novo Nordisk; Erasmus Medisch Centrum; Australian Schizophrenia Research Bank; British Heart Foundation; Ministry of Education, Culture, Sports, Science and Technology; Bundesministerium für Bildung und Forschung; ZonMw; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Institut National de la Santé et de la Recherche Médicale; Government of Ontario; National Institute for Health and Care Research; Pratt Foundation; Université de Bordeaux; Compute Canada; Fondation Bettencourt Schueller; Wellcome Trust; University of Alabama at Birmingham; University of Toronto; U.S. Department of Veterans Affairs; European Commission; School of Medicine, Boston University; Heart and Stroke Foundation of Canada; Stroke Association; Northwestern University; Suomen Lääketieteen Säätiö; EU Joint Programme – Neurodegenerative Disease Research; Bundesministerium für Wissenschaft, Forschung und Wirtschaft; U.S. Department of Health and Human Services","keywords":"Biology; Gene; Wnt signaling pathway; Brain size; Genetics; Human genome; Genome; Human brain; Neuroscience; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002124261,0.0003626286,0.0003543466,0.001267998,0.000418262,0.0004466844,0.0002415764,0.0004284026,0.004102325],"category_scores_gemma":[0.001286485,0.0001590168,0.0005118662,0.001653386,0.0004628437,0.0001890305,0.0004848847,0.0003231609,0.0003129635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001977214,"about_ca_system_score_gemma":0.0002437475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002396416,"about_ca_topic_score_gemma":0.002908377,"domain_scores_codex":[0.9997008,0.00006217258,0.00002064802,0.0001017856,0.00005969826,0.00005491601],"domain_scores_gemma":[0.999196,0.0002935108,0.0002844821,0.00009043068,0.00004379741,0.00009183295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009638832,0.00004757905,0.8977284,0.00008827035,0.0004678086,0.003453041,0.0002280956,0.0003457211,0.08041772,0.0006224312,0.0004845126,0.01515255],"study_design_scores_gemma":[0.00001239604,0.00005795308,0.9917664,0.000009993146,0.0001647776,0.00308955,0.00009332129,0.0002298789,0.003115554,0.0004047928,0.001046389,0.000008919837],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995809,0.001430617,0.0007342606,0.0001198057,0.00001085694,0.00000653115,0.0006050018,0.00003209405,0.001251957],"genre_scores_gemma":[0.9981967,0.000438982,0.0004263497,0.00003309544,0.0000138178,0.000005896634,0.0004193762,0.00001032545,0.0004555193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004102325,"threshold_uncertainty_score":0.01372361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01266641418731547,"score_gpt":0.2402220729085881,"score_spread":0.2275556587212726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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