{"id":"W4396626408","doi":"10.1016/j.xcrm.2024.101529","title":"Genetic variants for head size share genes and pathways with cancer","year":2024,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier Universitaire Sainte-Justine; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Center for Research Resources; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Mental Health; National Institute on Aging; Japan Society for the Promotion of Science; Ministerie van Onderwijs, Cultuur en Wetenschap; National Health and Medical Research Council; Siemens Healthineers; Medical Research Council; Canadian Institutes of Health Research; Wake Forest School of Medicine; University of Alabama; Macquarie Group Foundation; Agence Nationale de la Recherche; Universität Greifswald; National Institutes of Health; Heinz Nixdorf Stiftung; Ramsay Health Care; University College London Hospitals NHS Foundation Trust; Sanofi; Fondation de France; National Heart, Lung, and Blood Institute; Kaiser Foundation Research Institute; University of Minnesota; Vetenskapsrådet; Novo Nordisk; Erasmus Medisch Centrum; Australian Schizophrenia Research Bank; British Heart Foundation; Ministry of Education, Culture, Sports, Science and Technology; Bundesministerium für Bildung und Forschung; ZonMw; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Institut National de la Santé et de la Recherche Médicale; Government of Ontario; National Institute for Health and Care Research; Pratt Foundation; Université de Bordeaux; Compute Canada; Fondation Bettencourt Schueller; Wellcome Trust; University of Alabama at Birmingham; University of Toronto; U.S. Department of Veterans Affairs; European Commission; School of Medicine, Boston University; Heart and Stroke Foundation of Canada; Stroke Association; Northwestern University; Suomen Lääketieteen Säätiö; EU Joint Programme – Neurodegenerative Disease Research; Bundesministerium für Wissenschaft, Forschung und Wirtschaft; U.S. Department of Health and Human Services","keywords":"Biology; Gene; Wnt signaling pathway; Brain size; Genetics; Human genome; Genome; Human brain; Neuroscience; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009807351,0.0001261695,0.0001336931,0.00002118871,0.00006586638,0.00001924054,0.00003987814,0.0000659588,0.0001425186],"category_scores_gemma":[0.00002706261,0.00008752716,0.00002600637,0.00004466358,0.00006299324,0.000002813476,0.00002989903,0.00003619282,6.967934e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001024784,"about_ca_system_score_gemma":0.0001420832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009591551,"about_ca_topic_score_gemma":0.00005669265,"domain_scores_codex":[0.9992093,0.000008777746,0.0002049531,0.000333936,0.00008147884,0.0001614881],"domain_scores_gemma":[0.9995802,0.00002024257,0.00005689836,0.0001990751,0.00006755687,0.00007601269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007650087,0.00004371215,0.01633578,0.0008662422,0.0001732714,0.0004864924,0.000781614,0.0001202748,0.9568803,0.000131527,0.009892007,0.01421233],"study_design_scores_gemma":[0.001980892,0.002439016,0.05144853,0.0007749652,0.000558784,0.002969202,0.001198653,0.0005318681,0.2277236,0.001180305,0.7082726,0.000921572],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647689,0.03090833,0.001444763,0.0004023002,0.0004526665,0.000287548,0.00005441321,0.00002186039,0.001659236],"genre_scores_gemma":[0.9926829,0.001191178,0.0008315074,0.000168352,0.0006991305,0.0001046332,0.00008051485,0.00002546636,0.004216287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7291567,"threshold_uncertainty_score":0.3569254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01266641418731547,"score_gpt":0.2402220729085881,"score_spread":0.2275556587212726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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