{"id":"W4396626528","doi":"10.1182/blood.2024024251","title":"Motive and opportunity: <i>MYC</i> rearrangements in high-grade B-cell lymphoma with <i>MYC</i> and <i>BCL2</i> rearrangements (an LLMPP study)","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of Toronto; University Health Network; Terry Fox Research Institute; Simon Fraser University; BC Cancer Agency; University of British Columbia; Spinal Cord Injury BC","funders":"National Cancer Institute","keywords":"Somatic hypermutation; BCL6; Gene rearrangement; Biology; Lymphoma; Follicular lymphoma; Cancer research; Diffuse large B-cell lymphoma; B cell; Genetics; Germinal center; Gene; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365371,0.0001314324,0.0001038556,0.0004393083,0.0003075545,0.0003883688,0.0001763987,0.000320983,0.001926832],"category_scores_gemma":[0.0002330314,0.0001339494,0.0001297826,0.0002850216,0.0001956704,0.0002409367,0.0002927755,0.000284451,0.000291703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001592395,"about_ca_system_score_gemma":0.0001084201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001348226,"about_ca_topic_score_gemma":0.001778043,"domain_scores_codex":[0.9999349,0.00001043837,0.000003515932,0.00001811455,0.000009551926,0.00002352867],"domain_scores_gemma":[0.9998821,0.00002166184,0.00003149865,0.000006389325,0.00001369161,0.00004466945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006851468,0.0001828649,0.9703736,0.0000341641,0.00002662601,0.00245634,0.0005249953,0.00005156097,0.0190697,0.00006441041,0.0002585837,0.006272092],"study_design_scores_gemma":[0.00001270508,0.0002696808,0.9924259,0.000004380512,0.00002219113,0.004438779,0.0006559377,0.0002050338,0.001261337,0.00006039831,0.0006391997,0.00000442089],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996773,0.00003147766,0.00004421326,0.000007293125,5.90486e-7,0.000004302817,0.00005348218,0.000001485541,0.0001798861],"genre_scores_gemma":[0.9996636,0.00002374105,0.00004955352,0.00001177427,0.000002434167,0.000004317427,0.00008359736,0.000001744448,0.0001593096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001926832,"threshold_uncertainty_score":0.006445944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01652898056408345,"score_gpt":0.252295607740366,"score_spread":0.2357666271762825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}