{"id":"W4396633436","doi":"10.1186/s13039-024-00680-6","title":"Loss of heterozygosity impacts MHC expression on the immune microenvironment in CDK12-mutated prostate cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Cytogenetics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; University of Toronto; Ontario Institute for Cancer Research","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo; Government of Ontario","keywords":"Biology; Loss of heterozygosity; Immune system; Major histocompatibility complex; Cancer research; Tumor microenvironment; Prostate cancer; Immunology; Immunotherapy; Cancer; Genetics; Gene; Allele","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001563047,0.0001732836,0.0002161564,0.0001118707,0.00003795803,0.00002272603,0.000106891,0.00007019379,0.00009767252],"category_scores_gemma":[0.00001528532,0.0001051612,0.0001024855,0.0002482776,0.0001391525,0.00001743026,0.00009302542,0.0002375561,0.0000197782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002408067,"about_ca_system_score_gemma":0.0001297245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007120221,"about_ca_topic_score_gemma":0.000006371222,"domain_scores_codex":[0.9986994,0.00008441074,0.0002516657,0.0002733956,0.0003710837,0.0003201065],"domain_scores_gemma":[0.9994445,0.00003341424,0.00004074058,0.000360368,0.00003054518,0.00009047487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004351636,0.000191393,0.03080643,0.000223137,0.0001094823,0.0008125283,0.0006250163,0.0003974389,0.9642114,0.00001479547,0.0001336545,0.002039531],"study_design_scores_gemma":[0.0009619796,0.0004020434,0.02135489,0.0008749769,0.00005134644,0.00001387787,0.00004543175,0.0001363352,0.9751322,0.00005175396,0.0008780563,0.0000970498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759498,0.02014328,0.00003662793,0.00277286,0.00008035803,0.0008001731,0.00005274584,0.0000191969,0.0001449324],"genre_scores_gemma":[0.9947432,0.004549033,0.00007490973,0.0001526945,0.00001896654,0.0000842748,0.00003730091,0.00003695738,0.0003026819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01879336,"threshold_uncertainty_score":0.4288351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0185836833327883,"score_gpt":0.3047483747267482,"score_spread":0.2861646913939599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}