{"id":"W4396636687","doi":"10.1186/s12935-024-03329-x","title":"Iron metabolism: backfire of cancer cell stemness and therapeutic modalities","year":2024,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"Government of Jiangsu Province; Jiangsu University; National Natural Science Foundation of China","keywords":"Carcinogenesis; Cancer stem cell; Metastasis; Therapeutic modalities; Cancer research; Cancer; Cancer cell; Medicine; Regulator; Treatment modality; Immunotherapy; Modalities; Stem cell; Bioinformatics; Biology; Internal medicine; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006473013,0.00009600331,0.00008615944,0.00001895306,0.00002126497,0.00003145383,0.0001056055,0.00007039805,0.000386004],"category_scores_gemma":[0.000001917283,0.0000874004,0.00004900904,0.00002642018,0.00004660345,0.000006576417,0.00004901064,0.00003896787,0.000001267605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000315826,"about_ca_system_score_gemma":0.00007882364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008112508,"about_ca_topic_score_gemma":0.0003530548,"domain_scores_codex":[0.9994049,0.00001992912,0.0001461558,0.0002141342,0.0001235489,0.00009130985],"domain_scores_gemma":[0.9997249,0.00001106301,0.00004799936,0.00009851617,0.00008652288,0.00003103831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003246211,0.00002838343,0.002344242,0.0001587186,0.00008664874,6.54503e-7,0.0002807971,0.0006878974,0.9790136,0.0007504295,0.0002397007,0.01637642],"study_design_scores_gemma":[0.0002448163,0.00003175276,0.002777898,0.00003216772,0.00004759159,3.379881e-7,0.0001564339,0.001706183,0.9003742,0.0003093434,0.09418413,0.0001351031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7643138,0.2270832,0.0004814147,0.0001332078,0.0009225751,0.00006969092,0.000136098,0.000006515435,0.006853499],"genre_scores_gemma":[0.9706135,0.02380686,0.00008449191,0.00006520752,0.0003836002,0.00003991702,0.00005032354,0.00001760389,0.004938459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2062998,"threshold_uncertainty_score":0.4226473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01204553847698838,"score_gpt":0.2917755126624714,"score_spread":0.279729974185483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}