{"id":"W4396636708","doi":"10.1038/s41467-024-48231-2","title":"An oxylipin signal confers protection against antifungal echinocandins in pathogenic aspergilli","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Azrieli Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; International Development Research Centre; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Echinocandins; Echinocandin; Oxylipin; Aspergillus fumigatus; Microbiology; Biology; Aspergillosis; Aspergillus; Caspofungin; Fungal protein; Gliotoxin; Aspergillus nidulans; Amphotericin B; Antifungal; Biochemistry; Immunology; Enzyme; Gene; Fluconazole","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008636455,0.0001643396,0.0001145089,0.000121276,0.00006228396,0.0001663305,0.00009153484,0.0001688685,0.0008583263],"category_scores_gemma":[0.00008844078,0.00006444503,0.00009622419,0.00005764412,0.0001175062,0.0001195346,0.0001596053,0.0002237698,0.0001825696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001208636,"about_ca_system_score_gemma":0.00007326944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001893596,"about_ca_topic_score_gemma":0.0003031869,"domain_scores_codex":[0.9999321,0.00001189606,0.000006279517,0.00001470947,0.00001356478,0.00002146883],"domain_scores_gemma":[0.9999311,0.00001789023,0.00001775956,0.000008752836,0.000005802284,0.00001867927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002099327,0.000003324418,0.00006900173,0.000004045568,4.83e-7,0.00001719884,0.000002629395,0.00000832136,0.9996111,0.00002439987,0.000003516473,0.0002350727],"study_design_scores_gemma":[0.000006196563,0.0002078372,0.00733896,0.000002634702,0.000005453282,0.0002080898,0.00002448858,0.0004167283,0.991161,0.00004909785,0.000577667,0.000001937996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978878,0.0004083359,0.000885731,0.00004628758,0.000008998665,0.000004874903,0.00008610002,0.00002285956,0.0006488599],"genre_scores_gemma":[0.9987413,0.0001404411,0.000424316,0.0000247541,0.000003212138,0.000003596786,0.0001034225,0.000003251472,0.0005556746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008583263,"threshold_uncertainty_score":0.002871394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0301520522660692,"score_gpt":0.3368934058832159,"score_spread":0.3067413536171467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}