{"id":"W4396637460","doi":"10.1016/j.ejpb.2024.114310","title":"Charge-Switchable nanoparticles to enhance tumor penetration and accumulation","year":2024,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Nanoparticle; Drug delivery; Surface charge; Bioavailability; Biophysics; Drug; Chemistry; Extracellular; Nanotechnology; Drug carrier; Extravasation; Tumor microenvironment; Penetration (warfare); Pharmacology; Materials science; Cancer research; Tumor cells; Biochemistry; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006534949,0.0001802846,0.0001470397,0.00008770383,0.00007994813,0.0002435248,0.000209545,0.0002694936,0.0005409317],"category_scores_gemma":[0.0001455801,0.00008709342,0.0002216777,0.0000666722,0.0001197158,0.0002771806,0.0001664311,0.00015686,0.00007862721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002075484,"about_ca_system_score_gemma":0.0001747422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008388238,"about_ca_topic_score_gemma":0.0007671663,"domain_scores_codex":[0.9999741,0.000003974442,0.000001006274,0.0000060511,0.000009028564,0.000005821635],"domain_scores_gemma":[0.9999766,0.000009952807,0.000004895788,0.000001691281,0.000004066531,0.000002815367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001162995,0.0001283343,0.000526019,0.0001789073,0.00003143324,0.0003072224,0.00004118276,0.1882423,0.7791318,0.005083354,0.0003695215,0.02584361],"study_design_scores_gemma":[0.00006358582,0.0005437329,0.0008686171,0.000008109388,0.00004145959,0.000152718,0.00001993455,0.7909439,0.2011785,0.001707609,0.004449199,0.00002266451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8930103,0.00145002,0.09912253,0.0001759106,0.000094225,0.0000789197,0.00006311318,0.0002574177,0.005747669],"genre_scores_gemma":[0.9867802,0.0004510986,0.01131044,0.00004259776,0.000005510508,0.0000268741,0.00002356089,0.00001414802,0.001345544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008388238,"threshold_uncertainty_score":0.001809657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04903992881345656,"score_gpt":0.3491077872278262,"score_spread":0.3000678584143697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}