{"id":"W4396639677","doi":"10.1016/j.ahj.2024.05.002","title":"Obicetrapib on top of maximally tolerated lipid‐modifying therapies in participants with or at high risk for atherosclerotic cardiovascular disease: rationale and designs of BROADWAY and BROOKLYN","year":2024,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Tolerability; Ezetimibe; Cholesterylester transfer protein; Internal medicine; Placebo; Population; Clinical endpoint; Apolipoprotein B; Adverse effect; Lipoprotein; PCSK9; Cholesterol; Endocrinology; Pharmacology; Randomized controlled trial; LDL receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02900384,0.001845001,0.003659926,0.0007351709,0.001842612,0.001424904,0.001939305,0.002369442,0.006260284],"category_scores_gemma":[0.01497595,0.001058727,0.002559535,0.0007944555,0.001919725,0.001486967,0.001922418,0.00286653,0.0007818108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001436197,"about_ca_system_score_gemma":0.006664789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00198951,"about_ca_topic_score_gemma":0.005408562,"domain_scores_codex":[0.9745826,0.02052916,0.001329581,0.001707677,0.001145818,0.0007053263],"domain_scores_gemma":[0.9934813,0.002097892,0.001255548,0.0007856711,0.001049186,0.001330492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.7509125,0.01283796,0.02086726,0.006804348,0.003141058,0.0001966015,0.0008795116,0.001388881,0.008337351,0.007024802,0.006882675,0.1807271],"study_design_scores_gemma":[0.6535288,0.2175053,0.04799506,0.003371038,0.007581785,0.0002591991,0.0004635169,0.00437204,0.005095182,0.009058956,0.05052919,0.0002399512],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.43151,0.0484429,0.04632386,0.0094063,0.004009213,0.4280469,0.005591421,0.0004995695,0.02616983],"genre_scores_gemma":[0.5155688,0.006504103,0.07329525,0.005003623,0.0008127337,0.3941498,0.0008994006,0.00006134382,0.003704919],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.02900384,"threshold_uncertainty_score":0.1533888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05415988773599768,"score_gpt":0.2970085616947803,"score_spread":0.2428486739587827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}