{"id":"W4396674212","doi":"10.1101/2024.05.03.592454","title":"Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Phosphorylation; Calcium; Membrane; Chemistry; Cholesterol; Cell biology; Cluster (spacecraft); Biochemistry; Biophysics; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021167,0.0001673999,0.0002069492,0.0001486561,0.0003538403,0.0004242977,0.0002164458,0.0001943495,0.001056828],"category_scores_gemma":[0.0002521257,0.0001309029,0.0001801331,0.0001274259,0.0003276996,0.0002722636,0.0003544362,0.0003455255,0.0001631389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005974854,"about_ca_system_score_gemma":0.0002047145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001329749,"about_ca_topic_score_gemma":0.0009198315,"domain_scores_codex":[0.9999032,0.000012421,0.000005118533,0.0000223911,0.00002861758,0.00002824345],"domain_scores_gemma":[0.99989,0.00002893618,0.00003114475,0.000008333015,0.00001577245,0.00002589057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001180274,0.00003107907,0.000761868,0.00003290515,0.000009280765,0.0000397714,0.00002573937,0.001647821,0.9962286,0.0004262442,0.0001037228,0.0005750434],"study_design_scores_gemma":[0.00005381134,0.0001476566,0.0122262,0.0000114536,0.00002285196,0.00009278712,0.0001363919,0.07018555,0.91543,0.0005569463,0.001113379,0.00002300336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982235,0.0001164197,0.001012921,0.0000558601,0.000007906509,0.000007350626,0.00005136443,0.00001903232,0.0005056924],"genre_scores_gemma":[0.9994068,0.0000651043,0.0003496232,0.00001170139,0.000001598591,0.00000554091,0.00003499619,0.000005323866,0.0001193421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329749,"threshold_uncertainty_score":0.004335105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01731270143386084,"score_gpt":0.24951328427602,"score_spread":0.2322005828421591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}